basic FUNCTION
| being a non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA : DNA hybrids |
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participating in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication |
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mediating the excision of single ribonucleotides from DNA:RNA duplexes |
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may function to degrade RNA/DNA hybrids during cell death to avoid nucleic acid-mediated immune activation |
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may have a role in enzymatic activity of the RNAseH2 complex |
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ribonuclease H enzymes that specifically recognize RNA/DNA hybrids and hydrolyze the ribonucleotide-containing polynucleotide strand |
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SAMHD1, TREX1, and RNase H2 participate in a cellular nucleic acid metabolic pathway that overlaps the interferon-mediated innate antiviral and inflammatory responses |