Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNASEH2B contributors: mct - updated : 17-01-2014
HGNC name ribonuclease H2, subunit B
HGNC id 25671
Corresponding disease
AGS2 Aicardi-Goutieres syndrome 2
Location 13q14.3      Physical location : 51.483.891 - 51.544.594
Synonym name
  • deleted in lymphocytic leukemia 8
  • RNase H2 subunit B
  • Synonym symbol(s) FLJ11712, DLEU8
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 47.01 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1612 - 257 - 2009 19015152
    11 - 1613 - 312 - 2009 19015152
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunespleen    
     thymus   highly
    Nervousbrain    
    Reproductivemale systemprostate   
     male systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PIP-box and confers PCNA binding to RNase H2
  • mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • RNase H2 subunit B family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • beta subunit of the ribonuclease H2 enzyme complex which cleaves ribonucleotides from RNA: DNA duplexes
  • may function to degrade RNA/DNA hybrids during cell death to avoid nucleic acid-mediated immune activation
  • ribonuclease H enzymes that specifically recognize RNA/DNA hybrids and hydrolyze the ribonucleotide-containing polynucleotide strand
  • SAMHD1, TREX1, and RNase H2 participate in a cellular nucleic acid metabolic pathway that overlaps the interferon-mediated innate antiviral and inflammatory responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component RNase H2 is a heterotrimeric complex of the RNase H2A, RNase H2B, and RNase H2C proteins that are all required for proper function and activity
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNASEH2A interfaces mostly with the RNase H2C subunit that is intricately interwoven with the RNase H2B subunit
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AGS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    induce a CGAS/TMEM173-dependent innate immune response
    constitutional       loss of function
    are also associated with systemic lupus erythematosus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS