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FLASH GENE
Symbol RNASE3 contributors: mct - updated : 29
HGNC name ribonuclease, RNase A family, 3 (eosinophil cationic protein)
HGNC id 10046
Location 14q11.2      Physical location : 21.359.561 - 21.360.506
Synonym name cytotoxic ribonuclease
Synonym symbol(s) RNS3, ECP
EC.number 3.1.27.5
DNA
TYPE functioning gene
STRUCTURE 0.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratoryrespiratory tractlarynx   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight cysteine and histidine and lysine residues
  • HOMOLOGY
    Homologene
    FAMILY pancreatic ribonuclease family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text matrix of eosinophil's large specific granule
    basic FUNCTION
  • exhibits antibacterial activity
  • cytotoxin and helminthotoxin with low-efficiency ribonuclease activity
  • prodction and storage of the two ancestral proteins, RNASE3 and EPX likely share common regulatory mechanisms,
  • which result in opposing productions of the two proteins
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to allergy
  • to inflammatory bowel disease (IBD)
  • Variant & Polymorphism other
  • 434(G > C) polymorphism related to the development of allergic symptoms
  • polymorphisms of RNASE3 are associated to IBD in an age and gender dependent manner, suggesting an essential role of eosinophils in the pathophysiology of IBD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS