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FLASH GENE
Symbol RNASE2 contributors: - updated : 13-12-2006
HGNC name ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
HGNC id 10045
Location 14q11.2      Physical location : 21.423.629 - 21.424.594
Synonym symbol(s) RNS2, EDN
EC.number 3.1.27.5
DNA
TYPE functioning gene
STRUCTURE 0.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC123103 14q11.2 similar to kelch-like 4 isoform 2 OSGEP 14q11.1 O-sialoglycoprotein endopeptidase APEX1 14q11.2-q12 APEX nuclease (multifunctional DNA repair enzyme) 1 C14orf9 14q11.1 chromosome 14 open reading frame 9 NP 14q13.1 nucleoside phosphorylase LOC338879 14q11.2 similar to putative pancreatic ribonuclease LOC390443 14 similar to Ribonuclease-like protein 9 precursor C14orf6 14q11.1 chromosome 14 open reading frame 6 LOC254028 14q11.2 hypothetical protein LOC254028 LOC341799 14q11.2 similar to Olfactory receptor 6S1 RNASE4 14q11.2 ribonuclease, RNase A family, 4 ANG 14q11.2 angiogenin, ribonuclease, RNase A family, 5 RANBP20P 14 RAN binding protein 20 pseudogene FAM12A 14q11.1 family with sequence similarity 12, member A FAM12B 14q11.1 family with sequence similarity 12, member B (epididymal) RNASE6 14q11.2 ribonuclease, RNase A family, k6 RNASE1 14q11 ribonuclease, RNase A family, 1 (pancreatic) RNASE3 14q11.2 ribonuclease, RNase A family, 3 (eosinophil cationic protein) RNASE2 14q11.2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) FLJ20859 14q11.2 FLJ20859 gene SLC39A2 14q11.1 solute carrier family 39 (zinc transporter), member 2 NDRG2 14q11.2 NDRG family member 2 C14orf8 14q11.2 chromosome 14 open reading frame 8 RNASE7 14q11.1 ribonuclease, RNase A family, 7 RNASE8 14q11.1 ribonuclease, RNase A family, 8 FLJ10357 14q11.2 hypothetical protein FLJ10357 ZNF219 14q11 zinc finger protein 219 LOC387957 14 LOC387957 LOC390445 14 similar to Olfactory receptor 5AU1 LOC390446 14 similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; mammalian chromatin remodeling complex BRG1-associated factor 57 HNRPC 14q11.1 heterogeneous nuclear ribonucleoprotein C (C1/C2) RPGRIP1 14q11 retinitis pigmentosa GTPase regulator interacting protein 1 MRPS17P6 14p11 mitochondrial ribosomal protein S17 pseudogene 6 SUPT16H 14q11.1 suppressor of Ty 16 homolog (S. cerevisiae) HELSNF1 14q11.1 helicase with SNF2 domain 1 UBA52P2 14q11.2 ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 2 EIF4EBP1P 14 eukaryotic translation initiation factor 4E binding protein 1 pseudogene RAB2B 14q11.1 RAB2B, member RAS oncogene family C14orf92 14q11.1 chromosome 14 open reading frame 92
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunespleen    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight cysteine and histidine and lysine residues
  • N-terminal region necessary for mediating chemotactic activity
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Rnase2
    Homologene
    FAMILY pancreatic ribonuclease family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text matrix of eosinophil's large specific granule
    basic FUNCTION pyrimidine specific nuclease selectively chemotactic for dendritic cells
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS