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FLASH GENE
Symbol RLN3 contributors: mct - updated : 29-11-2014
HGNC name relaxin 3 (H3)
HGNC id 17135
Location 19p13.13      Physical location : 14.139.016 - 14.141.783
Genatlas name insulin-like 7
Synonym name
  • prorelaxin H3
  • insulin-like peptide 7
  • Synonym symbol(s) H3, RXN3, ZINS4, insl7
    DNA
    TYPE functioning gene
    STRUCTURE 2.77 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 452 - 142 - 2003 14522968
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrain   predominantly
     braindiencephalonhypothalamus   Homo sapiens
    Reproductivemale systemprostate    Homo sapiens
     male systemtestis    Homo sapiens
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY relaxin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a role in neuropeptide signaling processes
  • may act as a central signal linking nutritional status and reproductive function
  • hypothalamic neuropeptide that belongs to the insulin superfamily of peptides
  • may act as a hypothalamic signal to coordinate appetite, thyroid function, and reproductive status
  • neuropeptide that is implicated in the regulation of stress responses and memory
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component an A chain and a B chain
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is thought to act in the brain via the RXFP3 receptor, although the RXFP1 receptor may also play a role
  • RLN3 exerts antifibrotic actions via RXFP1 and may enhance the collagen-inhibitory effects of RLN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    metabolic syndrome is associated with increased serum relaxin-3 levels in women
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be considered as a potential biomarker of metabolic syndrome
  • Therapy target
    ANIMAL & CELL MODELS