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FLASH GENE
Symbol RITA1 contributors: npt/shn - updated : 03-05-2018
HGNC name RBPJ interacting and tubulin associated 1
HGNC id 25925
Location 12q24.13      Physical location : -
Synonym name
  • RBP-J interacting and tubulin associated
  • RBPJ-interacting and tubulin-associated protein
  • chromosome 12 open reading frame 52
  • Synonym symbol(s) FLJ14827, RITA, PSEC0043, C12orf52
    DNA
    TYPE functioning gene
    STRUCTURE 6.84 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D12S1616 - D12S1340 - C12orf52 - D12S1330 - D12S354 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1775 36 269 - 2017 28487372
    3 - 1921 - 293 - 2017 28487372
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Reproductivefemale systemuteruscervix predominantly
     female systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBPJ/CBF-1 (
  • is a novel RBPJ-interacting protein that downregulates NOTCH1-mediated transcription
  • might suppress tumor growth and induce apoptosis in hepatocellular carcinoma (HCC)
  • export RBPJ out of the nucleus, thereby leading to the down-regulation of Notch target gene expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tubulin (
  • is a RBPJ (mammalian CSL ortholog)-interacting protein
  • endogenous RBPJ and RITA1 interact in cells, map the binding regions necessary for RBP-J/RITA complex formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS