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FLASH GENE
Symbol RIT2 contributors: mct/npt - updated : 27/10/2008
HGNC name Ras-like without CAAX 2
HGNC id 10017
Location 18q12.3      Physical location : 40.323.192 - 40.695.657
Synonym name
  • GTP-binding protein Roc2
  • Ric (Drosophila)-like, expressed in neurons
  • Ric-like, expressed in neurons (Drosophila)
  • Synonym symbol(s) RIN, RIBA, ROC2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 372.47 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388474 18 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) NPM1P1 18q12.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 1 PIK3C3 18q12.3 phosphoinositide-3-kinase, class 3 LOC284260 18q12.3 hypothetical gene supported by BC011527; BC021928; BC011527; BC021928 RIT2 18q12.3 Ras-like without CAAX 2 SYT4 18q12.3 synaptotagmin IV LOC342732 18q21.1 similar to cytokeratin 8 LOC388475 18 LOC388475 SETBP1 18q21.1 SET binding protein 1 SLC14A2 18q12.1-q21.1 solute carrier family 14 (urea transporter), member 2 SLC14A1 18q12 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) LOC284266 KIAA1632 18q21.1 KIAA1632 protein PSTPIP2 18q12 proline-serine-threonine phosphatase interacting protein 2 ATP5A1 18q12-q21 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle LOC115106 MGC12909 18q21.1 hypothetical protein MGC12909 FLJ34218 18q21.1 hypothetical protein FLJ34218 FLJ32670 18q21.1 hypothetical protein FLJ32670
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1112 24.5 217 - Shi (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Rit2
    Homologene
    FAMILY
  • Ras subfamily of small guanine triphosphatases (GTPases)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • GTPase activity
  • may play an important roles in the regulation of signaling pathways and cellular processes distinct from those controlled by Ras
  • neuron-specific small GTPase that is involved in downstream signaling of plexin B3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP binding
  • protein
  • calmodulin binding
  • interacting with PLXNB3
  • interaction with POU4F1 (functional interaction with POU4F1, demonstrating the role of RIT2 in modulating the activation of the POU4F1 regulated EGR1 promoter by the N-terminal domain of POU4F1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS