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FLASH GENE
Symbol RIOK3 contributors: mct/npt/pgu - updated : 25-08-2013
HGNC name RIO kinase 3 (yeast)
HGNC id 11451
Location 18q11.2      Physical location : 21.032.786 - 21.063.097
Synonym name
  • sudD suppressor of bimD6 homolog (A. nidulans)
  • sudD suppressor of bimD6 homolog
  • sudD (suppressor of bimD6, Aspergillus nidulans) homolog
  • serine/threonine-protein kinase RIO3
  • Synonym symbol(s) SUDD, DKFZp779L1370
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 30.32 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    ROCK1 18q11.2 Rho-associated, coiled-coil containing protein kinase 1 LOC388471 18 similar to 60S RIBOSOMAL PROTEIN L21 LOC390839 18 similar to Endonuclease G like 1 (Endo G like) FLJ13687 EFO1 18q11.2 establishment factor-like protein SNRPD1 18q11.1 small nuclear ribonucleoprotein D1 polypeptide 16kDa ABHD3 18q11.1 abhydrolase domain containing 3 MIB 18q11.2 ubiquitin ligase mind bomb LOC201484 18q11.2 hypothetical LOC201484 GATA6 18q11.1-q11.2 GATA binding protein 6 CTAGE-1 18p11.2 CTAGE-1 protein CTAGE-2 18p11.2 CTAGE-2 LOC390840 18 similar to ribosomal protein S4, X-linked LOC390841 18 similar to ubiquitin-conjugating enzyme E2C isoform 2; ubiquitin carrier protein E2-C; ubiquitin-protein ligase C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme RBBP8 18q11.2 retinoblastoma binding protein 8 LOC91768 MGC11386 18q11.2 hypothetical protein MGC11386 RIOK3 18q11.2 RIO kinase 3 (yeast) C18orf8 18q11.2 chromosome 18 open reading frame 8 NPC1 18q11.1-q11.2 Niemann-Pick disease, type C1 LOC147463 18q11.2 hypothetical protein LOC147463 LOC390842 18 similar to 40S ribosomal protein S10 LAMA3 18q11.2 laminin, alpha 3 FLJ33761 18q11.2 hypothetical protein FLJ33761 CABYR 18q11.1 calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2) OSBPL1A 18q11-q12 oxysterol binding protein-like 1A IMPACT 18q11.2-q12.1 hypothetical protein IMPACT HRH4 18q11.2 histamine receptor H4 LOC390843 18 similar to hypothetical protein BC005868 LOC342741 18q11.2 similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 LOC147468 18q11.2 similar to WW domain binding protein 2 EHZF 18q11.2 early hematopoietic zinc finger SS18 18q11.2 synovial sarcoma translocation, chromosome 18 MGC26605 18q11.2 hypothetical protein MGC26605 TAF4B 18q11.2 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa KCTD1 18 potassium channel tetramerisation domain containing 1 LOC388472 18 hypothetical gene supported by BC002568 LOC342695 18q12.1 similar to ubiquitin fusion degradation 1-like AQP4 18q11.2.q12.1 aquaporin 4 FLJ30507 18q12.1 hypothetical protein FLJ30507 CHST9 18q11.2 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
    regionally located two microRNAs on the 18q11 amplicon (MIRN1-2 and MIRN133A1) could potentially play a role in pancreas ductal adenocarcinoma biology (PMID: 19050074)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 4035 59 519 - 1998 9602165
    - splicing 3589 - 424 - 1998 9602165
    an extra segment leading to a frameshift and an isoform with a distinct and shorter C-terminus
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RIO-like kinase domain
  • rich in glutamine, aspartic acid, serine and threonine residues
  • HOMOLOGY
    interspecies homolog to Aspergillus nidulans extragenic suppressor gene of the heat-sensitive bimD6 mutation
    homolog to murine Riok3
    homolog to rattus LOC361293
    Homologene
    FAMILY
  • RIO kinase family
  • protein kinase superfamily
  • RIO-type Ser/Thr kinase family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • protein kinase activity
  • involved in chromosome condensation and segregation
  • promotes cell migration through the activation of AKT1
  • mediator of pancreatic ductal cell migration and invasion
  • is a polyubiquitin binder
  • negatively regulates NF-kappaB signaling pathway activated by TNFalpha dependent on its kinase activity and NF-kappaB signaling pathway activated by caspase-10 independent of its kinase activity
  • cytoplasmic protein that does not seem to shuttle between nucleus and cytoplasm via a XPO1-dependent mechanism
  • is potentially a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells, required for normal processing of the 21S pre-rRNA
  • fFunctionally, RIOK3 acts as a SUFU-dependent positive regulator of HH signaling
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacted with caspase-10 (interaction was mediated by the RIO domain of RIOK3 and each death effector domain of CASP10)
  • is a novel modulator of SUFU subcellular distribution
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    alters cytoskeletal architecture as well as promotes pancreatic ductal cell migration and invasion
    tumoral     --over  
    in metastatic Head and Neck cancers compared with nonrecurrent tumors
    constitutional     --over  
    repressed NF-kappaB activity in a manner similar to optineurin, while siRNAs directed against ZFAND6 and RIOK3 also reduced NF-kappaB activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target point to the Rho signaling pathway as a focus for future cancer drug discovery efforts
    ANIMAL & CELL MODELS