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FLASH GENE
Symbol RIOK2 contributors: mct - updated : 28-11-2012
HGNC name RIO kinase 2 (yeast)
HGNC id 18999
Location 5q15      Physical location : 96.496.571 - 96.519.005
Synonym name
  • serine/threonine-protein kinase RIO2
  • Synonym symbol(s) FLJ11159
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 22.43 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3980 - 552 - -
    8 - 2240 - 474 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Riok2
    Homologene
    FAMILY RIO kinase family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • Ser/Thr kinase capable of autophosphorylation
  • its activity is essential for the recycling of TXNL4B, LTV1, and NOB1 as well as for 18S-E pre-rRNA processing
  • involved in late 40S maturation at several distinct steps
  • may have dual functions in ribosome biogenesis and cell proliferation
  • important regulator for controlling the proper timing of metaphase-anaphase transition, and its phosphorylation, most likely by PLK1, regulates its function
  • involved in maturation of the 40S ribosomal subunit precursors, that mobilizes several non-ribosomal proteins, including the atypical protein kinase RIOK2
  • shuttle between nucleus and cytoplasm via a XPO1-dependent mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a late 40S preribosomal particle in human cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLK1-mediated phosphorylation of RIOK2 regulates metaphase-anaphase transition during mitotic progression
  • novel substrate of PLK1 and its phosphorylation by PLK1 plays an important role in the regulation of proper metaphase-anaphase transition
  • cell & other
    REGULATION
    Phosphorylated by can be phosphorylated by PLK1, and its phosphorylation affects the metaphase-anaphase transition
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS