Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RIOK2 contributors: mct - updated : 28-11-2012
HGNC name RIO kinase 2 (yeast)
HGNC id 18999
Location 5q15      Physical location : 96.496.571 - 96.519.005
Synonym name
  • serine/threonine-protein kinase RIO2
  • Synonym symbol(s) FLJ11159
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 22.43 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ25680 5q15 hypothetical protein FLJ25680 FLJ12078 5q15 hypothetical protein FLJ12078 KIAA0825 5q15 KIAA0825 protein MGC34713 5q15 hypothetical protein MGC34713 DKFZp761C121 5q15 hypothetical protein DKFZp761C121 FLJ22344 5q15 hypothetical protein FLJ22344 LOC389310 5 LOC389310 FLJ25333 5q15 hypothetical protein FLJ25333 KIAA0372 5q13-q15 hypothetical protein FLJ25333 DKFZp313G1735 5q15 hypothetical protein DKFZp313G1735 LOC285601 5q15 seven transmembrane helix receptor LOC285601 LOC317671 5q15 LOC317671 SPATA9 5q15 spermatogenesis associated 9 RHOBTB3 5q21.2 Rho-related BTB domain containing 3 GLRX 5q14 glutaredoxin (thioltransferase) FIS 5q15 FIS ELL2 1q21-q25 elongation factor, RNA polymerase II, 2 PCSK1 5q15-q21 proprotein convertase subtilisin/kexin type 1 LOC389311 5 LOC389311 CAST 5q15-q21 calpastatin ARTS-1 5q15 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator LRAP 16 leukocyte-derived arginine aminopeptidase FLJ39485 5q15 hypothetical protein FLJ39485 LNPEP 5q21 leucyl/cystinyl aminopeptidase FLJ25534 5q15 hypothetical protein FLJ25534 RIOK2 5q14 RIO kinase 2 (yeast) LOC391812 5 similar to Dermatomyositis associated with cancer putative autoantigen-1 (DACA-1) LOC391813 5 similar to Zinc finger DHHC domain containing protein 3 (Zinc finger protein 373) (DHHC1 protein) LOC389312 5 similar to Proteasome activator complex subunit 2 (Proteasome activator 28-beta subunit) (PA28beta) (PA28b) (Activator of multicatalytic protease subunit 2) (11S regulator complex beta subunit) (REG-beta) LOC391814 5 similar to cytoplasmic beta-actin MRPS35P2 5q15 mitochondrial ribosomal protein S35 pseudogene 2 LOC285703 5q21.1 similar to C-terminal binding protein 2 isoform 2; ribeye LOC391815 5 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) FLJ90406 CHD1 5q15-q21 chromodomain helicase DNA binding protein 1 LOC389313 5 LOC389313 LOC256055 5q21.1 similar to Beta-glucuronidase precursor (Beta-G1) LOC285706 5q21.1 cytokine receptor-like factor 3 pseudogene LOC389314 5 similar to NADH dehydrogenase subunit 5 LOC389315 5 LOC389315
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3980 - 552 - -
    8 - 2240 - 474 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Riok2
    Homologene
    FAMILY RIO kinase family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • Ser/Thr kinase capable of autophosphorylation
  • its activity is essential for the recycling of TXNL4B, LTV1, and NOB1 as well as for 18S-E pre-rRNA processing
  • involved in late 40S maturation at several distinct steps
  • may have dual functions in ribosome biogenesis and cell proliferation
  • important regulator for controlling the proper timing of metaphase-anaphase transition, and its phosphorylation, most likely by PLK1, regulates its function
  • involved in maturation of the 40S ribosomal subunit precursors, that mobilizes several non-ribosomal proteins, including the atypical protein kinase RIOK2
  • shuttle between nucleus and cytoplasm via a XPO1-dependent mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a late 40S preribosomal particle in human cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLK1-mediated phosphorylation of RIOK2 regulates metaphase-anaphase transition during mitotic progression
  • novel substrate of PLK1 and its phosphorylation by PLK1 plays an important role in the regulation of proper metaphase-anaphase transition
  • cell & other
    REGULATION
    Phosphorylated by can be phosphorylated by PLK1, and its phosphorylation affects the metaphase-anaphase transition
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS