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FLASH GENE
Symbol RIOK1 contributors: mct/shn - updated : 23-12-2013
HGNC name RIO kinase 1 (yeast)
HGNC id 18656
Location 6p24.3      Physical location : 7.390.061 - 7.418.268
Synonym name
  • AD034 protein
  • serine/threonine-protein kinase RIO1
  • Synonym symbol(s) AD034, FLJ30006, bA288G3.1, MGC12903
    EC.number 2.7.1.37
    DNA
    TYPE functioning gene
    STRUCTURE 28.21 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 2495 65 568 - 2011 21081503
    10 splicing 1796 - 327 - 2011 21081503
    10 exons, a shorter N-terminus due to an alternate segment in the 5' coding region and a downstream in-frame translation start site
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the region AA 1242 comprises the so called Rio domain of RIOK1
  • HOMOLOGY
    interspecies ortholog to murine Riok1
    ortholog to rattus Riok1_predicted
    Homologene
    FAMILY
  • RIO-type serine/threonine-protein kinase family
  • protein kinase superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • predominantly cytoplasmic
  • basic FUNCTION
  • kinase activity
  • may be involved in cell cycle control
  • specifically promotes the symmetrical methylation of nucleolin by recruiting it to the PRMT5 complex
  • kinase activity of hRio1 is essential for the recycling of the endonuclease hNob1 and its binding partner hDim2 from cytoplasmic pre-40S
  • a role in the final stages of cytoplasmic pre-40S maturation
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitous component of the PRMT5 complex, the only component of the PRMT5 complex that localizes exclusively to the cytoplasm
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • PRMT5 through N-terminal part (aa 1291)
  • RIOK1 and CLNS1A might bind to the same site in PRMT5 and thus compete for binding
  • nucleolin
  • precursors of 40S ribosomal subunits
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • depletion of hRio1 by RNA interference affects the last step of 18S rRNA maturation and causes defects in the recycling of several trans-acting factors from pre-40S subunits in the cytoplasm