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FLASH GENE
Symbol RIMS2 contributors: mct - updated : 26-08-2013
HGNC name regulating synaptic membrane exocytosis 2
HGNC id 17283
Location 8q22.3      Physical location : 104.512.975 - 105.265.451
Synonym name
  • RAB3 interacting protein 3
  • non-small cell lung cancer RimL3a protein
  • Synonym symbol(s) OBOE, RIM2, RAB3IP3, KIAA0751, NIM2
    DNA
    TYPE functioning gene
    STRUCTURE 753.68 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392256 YWHAZ 2p25.2-p25.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide LOC51123 8q22.3 HSPC038 protein FKSG17 8q22.3 HSPC038 protein TFCP2L3 8q22.3 HSPC038 protein NCALD 8q22-q23 neurocalcin delta LOC392257 8 similar to IAP-associated factor VIAF1; phosducin-like 2 RRM2B 8q23.1 ribonucleotide reductase M2 B (TP53 inducible) DD5 8q22 ribonucleotide reductase M2 B (TP53 inducible) ODF1 8q22.3 outer dense fiber of sperm tails 1 TIEG 8q22.2 TGFB inducible early growth response OAZIN 8q22.3 ornithine decarboxylase antizyme inhibitor LOC389679 8 similar to hypothetical protein ATP6V1C1 8q22.3 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1 LOC389680 8 similar to MGC39526 protein BAALC 8q22.3 brain and acute leukemia, cytoplasmic FZD6 8q22.3-q23.1 frizzled homolog 6 (Drosophila) CTHRC1 8q22.3 collagen triple helix repeat containing 1 MFTC 8q22.3 mitochondrial folate transporter/carrier DKFZP564O0463 8q22.3 DKFZP564O0463 protein TARBP2P 8q22-q24 TAR (HIV) RNA binding protein 2 pseudogene RIMS2 8q22.3 regulating synaptic membrane exocytosis 2 DCSTAMP 8q23 DC-specific transmembrane protein DPYS 8q22 dihydropyrimidinase ST7 7q31.1-q31.3 suppression of tumorigenicity 7 LOC392258 8 similar to ribosomal protein L29 LOC392259 8 similar to KIAA0779 protein ZFPM2 8q22.3-q23 zinc finger protein, multitype 2 LOC346887 8q23.1 similar to hypothetical protein FLJ30794 OXR1 8q23 oxidation resistance 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 6797 - 1349 - 2003 12871946
    RIM2A
    22 - 6420 - 1163 - 2003 12871946
    RIM2B
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     neuroendocrinepituitary  highly
    Hearing/Equilibriumear   highly
    Nervousbrain   highly
    Reproductivefemale systemovary   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal zinc finger, ligand of 14-3-3 proteins, binding to RAB3 as a function of GTP
  • two C-terminal C2 domain, rabphilin-3A effector domain
  • a central PDZ domain
  • three C terminal SAM domains
  • HOMOLOGY
    interspecies homolog to murine Rabphilin 3A
    intraspecies homolog to RIMS1
    Homologene
    FAMILY RIM family of active zone proteins
    CATEGORY chaperone/stress , regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • synaptic
  • mitochondrial carrier protein
  • basic FUNCTION
  • integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitters release
  • regulating vesicle exocytosis during short-term plasticity
  • RIMS1 and RIMS2 are multidomain active zone proteins of presynaptic terminals
  • RIMS1 and RIMS2 are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis
  • component of the presynaptic active zone and modulator of exocytosis
  • piccolo, RIMS2, RIMS3, are involved in the neurobiology of schizophrenia
  • determines docking and priming states in insulin granule exocytosis
  • RIMS1, and RIMS2 co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic CaČ+ channel density and vesicle docking at the presynaptic active zone
  • mediate pyrimidine exchange in and out of vesicles
  • is a pyrimidine exchanger with an additional unique function in promoting mitochondrial iron utilization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB3A
  • interacting with RIMBP2 and BZRAP1
  • contributes to the stabilization of CACNA1D gating kinetics in immature cochlear inner hair cell
  • PNKD interacts with synaptic active zone proteins Rab3-interacting molecule (RIMS1) and RIMS2, localizes to synapses, and modulates neurotransmitter release
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS