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FLASH GENE
Symbol RIMBP3 contributors: mct/npt - updated : 09-02-2010
HGNC name RIMS binding protein 3
HGNC id 29344
Location 22q11.21      Physical location : 20.456.002 - 20.461.786
Synonym symbol(s) KIAA1666, LOC239731, RIM-BP3, RIMBP3A, DKFZp434H0735, RIMBP3B, RIMBP3C
DNA
TYPE functioning gene
STRUCTURE 5.80 kb     1 Exon(s)    3 Copie(s)
text structure three copies are present in the human genome
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 5796 - 1639 - Mittelstaedt (2007)
also called RIMBP3A
1 - 5802 - 1639 - Mittelstaedt (2007)
also called RIMBP3C
1 - 5429 - 1639 - Mittelstaedt (2007)
also called RIMBP3B
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three SH3-domains
  • three contiguous FNIII domains
  • HOMOLOGY
    Homologene
    FAMILY
  • RIMBP family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • potential role as important molecular adaptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the active zone proteins RIMS1 and RIMS2 as well as with different a-subunits of voltage-gated calcium channels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS