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FLASH GENE
Symbol RILPL2 contributors: mct - updated : 25-08-2016
HGNC name Rab interacting lysosomal protein-like 2
HGNC id 28787
Location 12q24.31      Physical location : 123.899.935 - 123.921.264
Synonym name
  • p40phox-binding protein
  • rab-interacting lysosomal protein-like 2
    • Synonym symbol(s) FLJ30380, FLJ32372, MGC7036, RLP2
    DNA
    TYPE functioning gene
    STRUCTURE 21.33 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1435 - 211 - 2004 14668488
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • RILPL1 and RILPL2 both localize to the primary cilium and centrosome
    • basic FUNCTION
  • MYO5A-interacting protein, regulating cellular morphology
  • potential role for RILPL2 in both the establishment and maintenance of dendritic spines
  • RILPL1 and RILPL2 regulate protein localization in the primary cilium
  • RILPL1 and RILPL2 function in regulation of ciliary membrane protein concentration by promoting protein removal from the primary cilium
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RILPL2 and the Rho GTPase RAC1 form a complex, and RILPL2 is able to induce activation of RAC1 and its target, p21-activated kinase PAK1
  • MYO5A is crucial for proper RILPL2 function
  • interaction of exogenous RILPL2 with TUBB3 resulted in the downregulation of Breast canncer cell proliferation and migration and upregulation of PTEN expression by promoting destabilization of TUBB3
  • RAB12 interacts with RILP, RILPL1 and RILPL2 independently of each other
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer (BC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS