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FLASH GENE
Symbol RILPL1 contributors: mct - updated : 29-08-2014
HGNC name Rab interacting lysosomal protein-like 1
HGNC id 26814
Location 12q24.31      Physical location : 123.955.908 - 124.018.265
Synonym name
  • RILP-like protein 1
  • GAPDH competitor of SIAH1 protein enhances life
  • Synonym symbol(s) FLJ39378, GOSPEL, MGC105128, MGC99793, RLP1
    DNA
    TYPE functioning gene
    STRUCTURE 62.36 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2624 52 403 - 2004 14668488
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • RILPL1 and RILPL2 both localize to the primary cilium and centrosome, RILPL1 specifically to the distal end of the mother centriole (pMID: 23264467)
  • is predominantly localized in the cytoplasm
  • basic FUNCTION
  • may physiologically regulate the viability of neurons and other cells
  • RILPL1 and RILPL2 regulate protein localization in the primary cilium
  • RILPL1 and RILPL2 function in regulation of ciliary membrane protein concentration by promoting protein removal from the primary cilium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds GAPDH, in competition with SIAH1, retaining GAPDH in the cytosol and preventing its nuclear translocation (
  • NPM1 did not compete with RILPL1 for GAPDH binding in the cytoplasm, although a small amount of NPM1 protein was able to reside in the cytoplasm
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS