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FLASH GENE
Symbol RILP contributors: mct - updated : 02-10-2012
HGNC name Rab interacting lysosomal protein
HGNC id 30266
Location 17p13.3      Physical location : 1.549.446 - 1.553.392
Synonym symbol(s) FLJ31193, PP10141
DNA
TYPE functioning gene
STRUCTURE 3.95 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MRPL14P1 17p13.3 chromosome 17 open reading frame 31 LOC390753 17 similar to putative protein LOC390754 17 similar to hypothetical class II basic helix-loop-helix protein LOST1 17p13.3 located at seventeen-p-thirteen point three 1 YWHAE 17p13.3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide CRK 17p13.3 v-crk sarcoma virus CT10 oncogene homolog (avian) MYO1C 17p13.3-p13.2 myosin IC SKIP 17p13 myosin IC PITPN 17p13.3 phosphotidylinositol transfer protein MGC34680 17p13.3 hypothetical protein MGC34680 RILP 17p13.3 hypothetical protein MGC34680 SCARF1 17p13.3 scavenger receptor class F, member 1 PRPF8 17p13.3 PRP8 pre-mRNA processing factor 8 homolog (yeast) LOC388317 17 LOC388317 MGC14376 17p13.3 hypothetical protein MGC14376 LOC388318 17 LOC388318 FLJ33817 17p13.3 hypothetical protein FLJ33817 SERPINF2 17p13 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 SERPINF1 17p13.3 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 KIAA1936 17p13.3 KIAA1936 protein RPA1 17p13.3 replication protein A1, 70kDa NGRH2 LOC388319 17 LOC388319 DPH2L1 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) OVCA2 17p13.3 diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae) HIC1 17p13.3 hypermethylated in cancer 1 C17orf31 17p13.3 chromosome 17 open reading frame 31 SRR 17q13.3 serine racemase LOC388320 17 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FLJ10534 17p13.3 hypothetical protein FLJ10534 KIAA0397 17p13.3 hypothetical protein FLJ10534
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1807 - 401 - 2004 14668488
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
 salivary gland    
 stomach    
Endocrineadrenal gland    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text heart, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil domain, RILP homology domain (RHD), and characterized as a common RAB36-binding site
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • playing a role in the control of transport to degradative compartments together with RAB7A and probably linking RAB7A function to the cytoskeleton
  • RAB7A and RILP are key proteins for the biogenesis of lysosomes and phagolysosomes
  • RILP could potentially have a role in the biogenesis of multivesicular bodies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • REST, DCTN1, HTT, HAP1, and RILP form a complex involved in the translocation of REST into the nucleus and HAP1 controls REST cellular localization in neurons
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SNF8 interacts with the N-terminal half of RILP
  • effector for the small GTPases RAB7A and RAB34
  • directly binds to DCTN1 dynactin subunit to recruit the dynein motor
  • RAB7A simultaneously binds RILP and ORP1L to form a RILP-RAB7A-ORP1L complex
  • bind to late endosomes via the RAB7A effector RAB7A-interacting lysosomal protein (RILP) in association with the oxysterol-binding protein ORP1L
  • interaction with RAB34
  • MREG interacted with the C-terminal domain of RILP and formed a complex with RILP and DCTN1 (dynein-dynactin motor complex recognizes MREG on mature melanosomes through interaction with RILP and is involved in the centripetal movement of melanosomes)
  • RAB36 mediates retrograde melanosome transport in melanocytes through interaction with RILP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS