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FLASH GENE
Symbol RICTOR contributors: mct/npt - updated : 03-09-2015
Location 5p13.1      Physical location : 38.938.021 - 39.074.501
Genatlas name rapamycin-insensitive companion of mTOR
Synonym name
  • TORC2-specific protein AVO3
  • pianissimo
  • Synonym symbol(s) KIAA1999, MGC39830, mAVO3, DKFZp686B11164
    DNA
    TYPE functioning gene
    STRUCTURE 136.48 kb     38 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    38 - 9535 - 1708 - 2008 18505677
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two distinct central regions critical for CRTC2 function
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • co-localized mostly with ER
  • basic FUNCTION
  • regulator of cytoskeletal dynamics, that regulates the ability of ILK to promote Akt phosphorylation and cancer cell survival
  • functional E3 ligase that associates with Cullin-1 and that this complex promotes SGK1 ubiquitination
  • important mediator of chemotaxis and metastasis in breast cancer cells
  • depending on its partner, can function in both polypeptide stabilization and degradation
  • multiple site acetylation of RICTOR stimulates CRTC2-dependent phosphorylation of AKT1 protein
  • by suppressing ARHGDIB, promotes activity of the Rho proteins and cell migration
  • critical function in T lymphopoiesis
  • RICTOR is involved in B cell development, especially the peripheral development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of mTORC2, a multiprotein kinase, complex implicated in Akt phosphorylation
  • RICTOR forms an E3 ligase complex with FBXW7 to regulate the protein stability of MYC and CCNE in colorectal cancer cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HSPA4 (putative Rictor interacting protein)
  • ILK-binding protein
  • interacting with MAPKAP1 (play an essential role in Akt phosphorylation and signaling)
  • interacting with PRR5
  • direct target of the ribosomal protein S6 kinase-1 (RPS6KB1)
  • associates with Cullin-1 to form a functional E3 ubiquitin ligase
  • RICTOR, but not Raptor or MTOR alone, promotes SGK1 ubiquitination
  • an intact CRTC2 is required for efficient binding of MTOR, and rictor to translating ribosomes
  • important component of FBXW7 E3 ligase complex participating in the regulation of MYC and CCNE protein ubiquitination and degradation
  • regulates cell migration by controlling a potent inhibitor of Rho proteins known as the Rho-GDP dissociation inhibitor 2 (ARHGDIB)
  • RICTOR and its binding partner SIN1 are indispensable components of CRTC2 (mammalian target of rapamycin complex 2)
  • specific domains of MTOR, RICTOR, or MAPKAP1 interacted with the internal domain (AA. 221-402) of NBN
  • CHUK and IKBKB physically interacted with RICTOR
  • RICTOR positively regulates the early events of BCR signaling
  • RICTOR positively regulates B cell receptor signaling by modulating actin reorganization via EZR
  • cell & other
    REGULATION
    Other phosphorylated by overexpression of PINK1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in well-differentiated leiomyosarcomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • :
  • Rictor null mice exhibited mild hyperglycemia and glucose intolerance caused by a reduction in &
    946;-cell mass, &
    946;-cell proliferation, pancreatic insulin content, and glucose-stimulated insulin secretion