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FLASH GENE
Symbol RIC8B contributors: mct - updated : 05-05-2015
HGNC name RIC8 guanine nucleotide exchange factor B
HGNC id 25555
Location 12q23.3      Physical location : 107.168.398 - 107.283.092
Synonym name
  • synembryn-B
  • brain synembrin
  • resistance to inhibitors of cholinesterase 8 homolog B
  • Synonym symbol(s) RIC8, hSyn
    DNA
    TYPE functioning gene
    STRUCTURE 115.03 kb     9 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure
  • during osteoblast differentiation, RIC8B gene repression is accompanied by changes in nucleosome placement at the proximal RIC8B gene promoter and reduced accessibility to regulatory sequences
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4989 - 520 - 2006 16754875
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • RIC8A, RIC8B act together with GNAQ regulating neuronal transmitter release
  • plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling
  • RIC8A and and RIC8B are guanine nucleotide exchange factors that enhance different heterotrimeric guanine nucleotide-binding protein (G protein) signaling pathways
  • RIC8A, RIC8B act as non-receptor GEF activators of G proteins in signal transduction contexts will be weighed against the evidence supporting the molecular chaperoning function of RIC8 in promoting G protein abundance
  • RIC8A, RIC8B directly participates in the posttranslational folding of nascent Galpha subunits to promote G-protein biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by CEBPB (is negatively regulated during osteoblast differentiation by the transcription factor CEBPB)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and CEBPB-mediated manner
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS