basic FUNCTION
| required for the maturation of multiple nicotinic acetylcholine receptors (nAChRs) |
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promoting functional expression of the nicotinic acetylcholine receptor alpha7 subunit in cells |
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can act as a specific regulator of receptor expression at different levels |
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might play a key role in the biogenesis of some ligand-gated receptors and prompted us to investigate how it performs its action |
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in neurons, RIC3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting CHRNA7 trafficking to dendrites and preventing axonal transport |
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modulates the expression of CHRNA7 in a subtype-specific manner |
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RIC3 differentially regulates assembly and expression of different nicotinic receptor subunits |