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FLASH GENE

Symbol

RIC3

contributors: mct - updated : 23-01-2018

HGNC name	resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
HGNC id	30338

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.4      Physical location : 8.127.596 - 8.190.590
Genatlas name	RIC3 protein
Synonym symbol(s)	FLJ11608, AYST720, PRO1385, RIC-3

DNA

TYPE	functioning gene
STRUCTURE	76.12 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	RIC3 alternative splicing enables subtype specific regulation of CHRNA7 maturation (PMID: 19116311) alternatively spliced to produce multiple isoforms (PMID: 27129882)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001135109 - - 5335 NP_001128581 - 187 - 2008 18691158 NM_001206671 - - 5881 NP_001193600 - 369 - 2008 18691158 NM_001206672 - - 5638 NP_001193601 - 288 - 2008 18691158 NM_001346690 - - 6014 NP_001333619 - 207 - 2008 18691158 NM_001346691 - - 5732 NP_001333620 - 176 - 2008 18691158 NM_001346692 - - 5927 NP_001333621 - 319 - 2008 18691158 NM_001346693 - - 5732 NP_001333620 - 176 - 2008 18691158 NM_001346694 - - 5927 NP_001333621 - 319 - 2008 18691158 NM_024557 - - 5878 NP_078833 - 368 - 2008 18691158

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Lymphoid/Immune spleen       highly Reproductive male system prostate       Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two transmembrane domains
	a C-terminal coiled-coil domain (CC-I)

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus
text	endoplasmic reticulum-resident protein

basic FUNCTION	required for the maturation of multiple nicotinic acetylcholine receptors (nAChRs)
	promoting functional expression of the nicotinic acetylcholine receptor alpha7 subunit in cells
	can act as a specific regulator of receptor expression at different levels
	might play a key role in the biogenesis of some ligand-gated receptors and prompted us to investigate how it performs its action
	in neurons, RIC3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting CHRNA7 trafficking to dendrites and preventing axonal transport
	modulates the expression of CHRNA7 in a subtype-specific manner
	RIC3 differentially regulates assembly and expression of different nicotinic receptor subunits

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	acts as a regulator of acetylcholine nicotinic receptor (nAChR) expression
	RIC3 is a known chaperone of neuronal CHRNA7
	nicotinic acetylcholine receptor-specific chaperone

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS