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FLASH GENE
Symbol RHPN2 contributors: npt/ - updated : 13-10-2004
HGNC name rhophilin, Rho GTPase binding protein 2
HGNC id 19974
Location 19q13.11      Physical location : 33.469.498 - 33.555.824
Synonym name
  • rhophilin-2
  • GTP-Rho-binding protein 2
  • rhophilin-like protein
  • 76 kDa RhoB effector protein
  • Synonym symbol(s) p76RBE, RHOBP
    DNA
    TYPE functioning gene
    STRUCTURE 86.30 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1474 LOC388529 19 LOC388529 LOC147941 19q13.12 hypothetical LOC147941 LOC147942 19q13.12 hypothetical LOC147942 LOC388530 19 LOC388530 ZNF507 19q13.12 zinc finger protein 507 LOC147991 19q13.12 hypothetical protein LOC147991 DKFZP434L0718 PDCD5 19q13.1 programmed cell death 5 LOC388531 19 similar to regulator of G protein signaling 9-binding protein; RGS9-1 anchor; RGS9 anchor protein LOC390916 19 similar to RP2 protein, testosterone-regulated - ricefield mouse (Mus caroli) FLJ13072 19q13.12 hypothetical gene FLJ13072 SLC7A9 19q13.1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 FLJ14640 19q13.12 hypothetical protein FLJ14640 MGC32020 19q13.12 hypothetical protein MGC32020 RHPN2 19q13.12 rhophilin, Rho GTPase binding protein 2 ECGP 19q13.12 evolutionarily conserved G-patch domain containing LOC126248 19q13.12 hypothetical protein LOC126248 LRP3 19q12-q13.2 low density lipoprotein receptor-related protein 3 SLC7A10 19q12-q13.1 solute carrier family 7, (cationic amino acid transporter, y+ system) member 10 CEBPA 19q13.1 CCAAT/enhancer binding protein (C/EBP), alpha FLJ12355 19q13.12 hypothetical protein FLJ12355 LOC126242 19q13.12 similar to Aldose reductase (AR) (Aldehyde reductase) CEBPG 19q13.12 CCAAT/enhancer binding protein (C/EBP), gamma PEPD 19q13.1 peptidase D LOC388532 19 similar to 60S ribosomal protein L21 CHST8 19q13.1 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 KCTD15 19q13.12 potassium channel tetramerisation domain containing 15 LOC390917 19 similar to ribosomal protein S4 LOC126235 19q13.12 similar to ribosomal protein S4, X-linked LOC390918 19 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein DKFZP434D1335 KIAA0355 19q13.12 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein GPI 19q13.1 glucose phosphate isomerase MGC13096 19q13.12 hypothetical protein MGC13096 UBA2 9q12 hypothetical protein MGC13096 LOC126374 19q13.12 similar to LIM domains containing 1 LOC390919 19 similar to ZNF140-like transcription factor LOC390920 19 similar to zinc finger protein 2 ZNF302 19q13.2 zinc finger protein 302
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3546 - 686 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     liver    
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal Rho-binding domain
  • a Bro-1 like domain
  • a C-terminal PDZ domain that could mediate protein-protein interactions
  • HOMOLOGY
    interspecies homolog to murine Rhpn2
    intraspecies homolog to LOC283964
    Homologene
    FAMILY
  • RHPN family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • may be implicated in the stimulation of the thyrotropin/cAMP pathway in thyrocytes
  • may have a role in the Rho pathway, regulating actin cytoskeleton organization, limiting stress fiber formation and/or increasing the turn-over of F-actin in absence of high level of RhoA activity
  • may be implicated in targeting or scaffolding processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GDP- and GTP-bound RhoA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS