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FLASH GENE
Symbol RHOXF2 contributors: mct - updated : 19-06-2020
HGNC name Rhox homeobox family, member 2
HGNC id 30011
Location Xq24      Physical location : 119.206.240 - 119.297.933
Genatlas name PEPP subfamily gene 2
Synonym name
  • Testis homeobox gene 1
  • cancer/testis antigen 107
  • homeobox protein from AL590526
  • Synonym symbol(s) PEPP2, PEPP-2, THG1, CT107
    DNA
    TYPE functioning gene
    STRUCTURE 7.09 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1297 - 288 - Lehner (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   lowly
    Reproductivefemale systemuterus  lowly
     male systemtestis    Homo sapiensFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a homeobox domain
    HOMOLOGY
    interspecies ortholog to murine Rhox gene cluster (one or more members)
    Homologene
    FAMILY
  • paired-like homeobox family
  • PEPP subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating downstream genes and biological events in the testis
  • having conserved roles in the reproductive tract
  • testis-restricted or testis-selective protein (Hofmann 2008)
  • is involved in carcinogenesis
  • is a fast-evolving homeobox gene in primates
  • its expression increases in the second trimester during fetal testes development when gonocytes differentiate into prespermatogonia
  • potential role of RHOXF2 in regulating function of membrane and microtubules
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer , and was correlated with higher stages of tumors
    tumoral     --over  
    in some leukemia cell lines and a variety of human cancer samples including colon and lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ODF4 and RHOXF2 are proposed as putative breast cancer biomarkers at the transcript level
  • Therapy target
    ANIMAL & CELL MODELS