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FLASH GENE
Symbol RHOXF1 contributors: mct - updated : 21-03-2008
HGNC name Rhox homeobox family, member 1
HGNC id 29993
Location Xq24      Physical location : 119.243.024 - 119.249.847
Synonym name
  • ovary, testis- and epididymis- expressed gene protein
  • paired-like homeobox protein PEPP-1
  • paired-like homeobox protein OTEX
  • Synonym symbol(s) PEPP1, MGC119030, MGC119033, OTEX
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 755 20 184 - Lim (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis   
     male systemmale genital tractepididymis  
    cell lineage
    cell lines erythroleukemia cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a glutamine-rich N terminus
  • a homeobox DNA-binding domain
  • a proline-rich C terminus
  • one OAR domain
  • HOMOLOGY
    interspecies ortholog to murine Rhox gene cluster (one or more members)
    Homologene
    FAMILY
  • paired-like homeobox family
  • PEPP subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in normal eye anterior-chamber and lens development
  • paired-like homeobox protein, with possibly an important role in human reproduction
  • having conserved roles in the reproductive tract
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text gametogenesis
    PATHWAY
    metabolism
    signaling hormonal
    steroid hormone receptor signaling pathway
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by androgens
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS