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FLASH GENE
Symbol RHOQ contributors: npt/ - updated : 25-05-2011
HGNC name ras homolog gene family, member Q
HGNC id 17736
Location 2p21      Physical location : 46.769.866 - 46.811.825
Synonym name
  • ras-like protein,small GTP binding protein
  • ras-like protein TC10
  • RAS-like, family 7, member A
  • Synonym symbol(s) ARHQ,TC10, TC10A , RASL7A
    DNA
    TYPE functioning gene
    STRUCTURE 41.96 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4542 22.53 205 - 2002 11821390
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RAS domain
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to murine Tc10l
    intraspecies homolog to RAC3
    homolog to CDC42
    homolog to RAC1
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rho family
  • CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text cholesterol enriched microdomains (lipid rafts)
    basic FUNCTION
  • involved in the control of microfilament assembly
  • playing a role in insulin stimulated glucose uptake and GLUT4 (SLC2A4) translocation
  • specifically required for insulin-stimulated glucose uptake in adipocytes
  • RHOQ and EXOC7 are essential for the polarized externalization of IGF1 receptor, and this process is necessary for axon specification
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text intracellular lipid and protein transport
    PATHWAY
    metabolism
    signaling
    signaling pathway in skeletal muscle that involves obscurin and the Rho GTPase RHOQ and implicate this pathway in new sarcomere formation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulating both total and plasma membrane CFTR expression by interacting with CFTR-associated ligand (CAL/GOPC)
  • OBSCN is a specific activator of RHOQ but not the Rho GTPases RAC1 and CDC42
  • cell & other
    REGULATION
    activated by GRF2 (C3G-CRK complex) in lipid rafts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    elevated Rhoq activity contributes to v-Rel-transformed chicken embryonic fibroblasts and demonstrate for the first time that a Rho factor alone is capable of inducing the transformation of primary cells (Tong 2007)