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FLASH GENE
Symbol RHOJ contributors: mct - updated : 10-01-2017
HGNC name ras homolog gene family, member J
HGNC id 688
Location 14q23.1      Physical location : 63.671.144 - 63.758.559
Synonym name
  • TC10-like Rho GTPase
  • RAS-like, family 7, member B
  • Synonym symbol(s) TCL,TC10B, FLJ14445, RASL7B, ARHJ
    DNA
    TYPE functioning gene
    STRUCTURE 86.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vessel   predominantly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP , Other
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to Drosophila cg8500
    homolog to C.elegans c54a12.4
    ortholog to murine Rhoj
    ortholog to rattus rhoj_predicted
    intraspecies homolog to TC10
    homolog to CDC42
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rho family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • GTPase playing a role in the actin filament organization
  • involved in insulin-stimulated glucose transport
  • GIT1, GIT2, ARHGEF7 and RHOJ all colocalised in focal adhesions and depended on each other for their recruitment to focal adhesions
  • molecular function of RHOJ in regulating cell motility and tumour vessel formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein binding to CDC42/Rac interacting binding domain of PAK or WASP
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis