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FLASH GENE
Symbol RHOG contributors: mct/pgu - updated : 25-08-2015
HGNC name ras homolog gene family, member G (rho G)
HGNC id 672
Location 11p15.4      Physical location : 3.848.207 - 3.862.213
Synonym name Rho-related GTP-binding protein RhoG
Synonym symbol(s) ARHG, MGC125835, MGC125836
DNA
TYPE functioning gene
STRUCTURE 14.01 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1332 - 191 - 1997 9177787
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix  
 female systemovary   
Skin/Tegumentskin    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet Homo sapiens
cell lineage
cell lines
fluid/secretion blood
at STAGE
Text expressed in the ventricular zone at early stages of cortical development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
HOMOLOGY
interspecies ortholog to murine Rhog
homolog to zebrafish wufk30f01
Homologene
FAMILY
  • small GTPase superfamily
  • Rho family
  • CATEGORY regulatory , protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • coordinated assembly of focal adhesions and stress fibers
  • linking growth factor receptors to the activation of actin polymerization
  • role in signaling the neutrophil respiratory burst stimulated by G protein-coupled receptor agonists
  • playing a critical role in muscle differentiation
  • mediating the distinct actin cytoskeleton
  • changes required for both cellular motility and cell-cell adhesion
  • potentially promoting neural progenitor cells proliferation through PI3K in cortical development
  • functions upstream of the ELMO1/DOCK1 complex, and is also important for spine formation
  • functions to promote spine morphogenesis
  • RAC1 is required for ICAM1 clustering, whereas RHOG controls membrane protrusion formation
  • critical role for RHOG in glioblastoma tumor cell invasion and survival
  • orchestrates processes integral to platelet function, including actin cytoskeletal rearrangement and membrane trafficking
  • functions of RhoG in platelets are particularly relevant to thrombotic disorders
  • RHOG is essential for normal granule secretion downstream of the collagen receptor GP6
  • exogenous expression of ELMO2 or RHOG stabilizes microtubules, but only if ILK is also present
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    new signaling pathway involving RHOG and its exchange factor SGEF downstream from ICAM1 that is critical for leukocyte trans-endothelial migration
    a component
  • forms a complex with ezrin and PLEKHG6
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • putative regulator of myogenin and MEF25 genes
  • ICAM1 colocalizes with RHOG and binds to the RHOG-specific SH3-containing guanine-nucleotide exchange factor (SGEF)
  • interaction with ILK (interaction with ELMO2 and RHOG is essential for the ability of ILK to induce front-rear cell polarity)
  • SNX1 and SNX2 interact directly with inactive RHOG, suggesting a novel role for these SNX proteins in recruiting an inactive Rho GTPase to its exchange factor
  • ARHGEF16 is a guanine nucleotide exchange factor (GEF) for RHOG that interacts with EPHA2 in breast cancer cells
  • ARHGEF16 mediates resistance to anoikis through activation of RHOG and PI3K downstream of EPHA2
  • upon clustering of ICAM1, the Rho-guanine nucleotide exchange factor TRIO activates RAC1, prior to activating RHOG, in a filamin-dependent manner
  • NAV1 interacts and colocalizes with TRIO, a Rho guanine nucleotide exchange factor that enables neurite outgrowth by activating the Rho GTPases RAC1 and RHOG
  • cell & other
    REGULATION
    activated by PLEKHG
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS