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FLASH GENE
Symbol RHOF contributors: mct - updated : 12-04-2023
HGNC name ras homolog gene family, member F (in filopodia)
HGNC id 15703
Location 12q24.31      Physical location : 122.215.661 - 122.231.594
Synonym name
  • Rho in filopodia
  • Rho-related GTP-binding protein RhoF
  • Rho-family GTPase Rif
  • Synonym symbol(s) ARHF, FLJ20247, RIF
    EC.number 3.6.5.4 /3.6.5.1 EC 3.6.5.23.6.5.3/3.6.5.2/ 3
    DNA
    TYPE functioning gene
    STRUCTURE 15.93 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2435 - 211 - 2015 25668492
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique domain organisation, with tandem GTP-binding domains
  • two EF hand domains
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to murine Arhd, Arhc
    homolog to rattus Arhb, Arha2
    homolog to yeast S.cerevisiae Rho1p, Cdc42p
    homolog to C.elegans rho1
    homolog to Drosophila rho1, rac2
    intraspecies homolog to ARHD
    homolog to RAC2
    Homologene
    FAMILY
  • Ras superfamily of GTP- binding proteins
  • Rho GTPase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in actin filament organization by generating filopodial structures (Carbone 2008)
  • has the conserved Rho GTPase domain structures and cycles between a GDP-bound inactive form and a GTP-bound active form
  • RHOF provides an alternative route to filopodia generation in other cell types and is expressed in platelets
  • functional overlap between RHOF and other small GTPases may be responsible for the non-essential role of RHOF in platelets
  • RHOF promotes likely marginal zone(MZ) B cell development in the spleen
  • in combination with RAC1 and CDC42, causing actin rearrangments that suggesting its involvement in regulation of the cytoskeleton
  • RHOF shares a conserved mechanism of GTP hydrolysis with other RAS superfamily GTPases
  • regulates the formation of filopodia and stress fibers in cells
  • is indispensable for both extracellular and intracellular pattern-recognition receptor-mediated innate immune responses
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • found to be an integral part of the TLR4, TLR3 and nodosome signaling complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • RAC1
  • CDC42
  • interacts with FARP1, a neuronal activator of the RhoA GTPase
  • RHOF interacts with the I-BAR family protein IRTKS (also known as BAIAP2L1) through its I-BAR domain
  • EPS8 regulates the size and number of dorsal filopodia and membrane ruffles downstream of RHOF-BAIAP2L1 signaling, whereas WASF2 modulates dorsal membrane ruffling
  • RHOF is required for NFKB1 activation by KLF4 in esophageal keratinocytes and is also important for esophageal keratinocyte proliferation and migration
  • cell & other
    REGULATION
    activated by KLF4 in esophageal keratinocytes, leading to the induction of NFKB1 signaling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in eosinophilic esophagitis, an important esophageal inflammatory disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS