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FLASH GENE
Symbol RHOF contributors: mct - updated : 11-03-2009
HGNC name ras homolog gene family, member F (in filopodia)
HGNC id 15703
Location 12q24.31      Physical location : 122.215.661 - 122.231.594
Synonym name
  • Rho in filopodia
  • Rho-related GTP-binding protein RhoF
  • Rho-family GTPase Rif
  • Synonym symbol(s) ARHF, FLJ20247, RIF
    DNA
    TYPE functioning gene
    STRUCTURE 15.93 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2451 - 211 - Carbone (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique domain organisation, with tandem GTP-binding domains
  • two EF hand domains
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to murine Arhd, Arhc
    homolog to rattus Arhb, Arha2
    homolog to yeast S.cerevisiae Rho1p, Cdc42p
    homolog to C.elegans rho1
    homolog to Drosophila rho1, rac2
    intraspecies homolog to ARHD
    homolog to RAC2
    Homologene
    FAMILY Ras superfamily of GTP- binding proteins
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in actin filament organization by generating filopodial structures (Carbone 2008)
  • in combination with RAC1 and CDC42, causing actin rearrangments that suggesting its involvement in regulation of the cytoskeleton
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • RAC1
  • CDC42
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS