Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RHOC contributors: mct/npt/pgu - updated : 14-06-2017
HGNC name ras homolog gene family, member C
HGNC id 669
Location 1p13.1      Physical location : 113.243.748 - 113.250.025
Synonym name
  • Rho-related GTP-binding protein RhoC
  • oncogene RHO H9
  • small GTP binding protein RhoC
  • Synonym symbol(s) RHOH9, ARH9, ARHC, MGC61427, MGC1448, H9
    DNA
    TYPE functioning gene
    STRUCTURE 6.28 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text all transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1415 - 193 - 2009 19477269
    6 - 1313 - 193 - 2009 19477269
    5 - 1346 - 193 - 2009 19477269
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     liver    
    Nervousbrain    
    Skin/Tegumentskin   predominantly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP
    HOMOLOGY
    interspecies homolog to Aplysia Ras-related C
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rho family
  • CATEGORY regulatory , protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • GTPase, GTP binding protein (signal transduction)
  • coordinated assembly of focal adhesions and stress fibers
  • linking growth factor receptors to the activation of actin polymerization
  • with RHOA, are essential for tumor invasion and/or metastasis in breast carcinomas
  • playing a critical role in muscle differentiation
  • mediating the distinct actin cytoskeleton
  • changes required for both cellular motility and cell-cell adhesion
  • responsible for stress fibre formation and inhibiting its expression reduces EMT-induced migration
  • RHOA, RHOB and RHOC all have the potential to interact with the same downstream effectors, yet they have substantially different effects on cell shape and migratory properties
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • putative regulator of myogenin and MEF25 genes
  • actin
  • potential binding partner for RHOC (LNX1, LNX2 and RHOC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1)
  • RHOC promotes polarized migration through FMNL3 by restricting lamellipodial broadening (
  • RHOA and RHOC are both required for the ROCKent promotion of centrosome duplication
  • RHOC, and RAC1 are essential, for IGFBP1-induced extravillous trophoblast (EVT migration
  • PKN3 physically interacts with Rho-family GTPases, and preferentially with RHOC, a known mediator of tumor invasion and metastasis in epithelial cancers
  • ARHGAP21 presented GAP activity for RHOA and RHOC and induced changes in cell morphology
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic melanoma
    tumoral     --over  
    Rho enhances the in vitro migration and invasion of melanocells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    PKN3-RHOC complex represents an attractive therapeutic target in late-stage malignancies
    ANIMAL & CELL MODELS