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Symbol RHOBTB3 contributors: mct/npt - updated : 31-05-2014
HGNC name Rho-related BTB domain containing 3
HGNC id 18757
Location 5q15      Physical location : 95.066.849 - 95.132.069
Synonym symbol(s) KIAA0878
TYPE functioning gene
STRUCTURE 65.22 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391810 5 similar to T-complex protein 1, eta subunit (TCP-1-eta) (CCT-eta) (HIV-1 Nef interacting protein) LOC391811 5 similar to DNA polymerase delta subunit 2 NR2F1 5q14 nuclear receptor subfamily 2, group F, member 1 LOC389309 5 LOC389309 DKFZP564D172 5q15 hypothetical protein DKFZp564D172 FLJ25680 5q15 hypothetical protein FLJ25680 FLJ12078 5q15 hypothetical protein FLJ12078 KIAA0825 5q15 KIAA0825 protein MGC34713 5q15 hypothetical protein MGC34713 DKFZp761C121 5q15 hypothetical protein DKFZp761C121 FLJ22344 5q15 hypothetical protein FLJ22344 LOC389310 5 LOC389310 FLJ25333 5q15 hypothetical protein FLJ25333 KIAA0372 5q13-q15 hypothetical protein FLJ25333 DKFZp313G1735 5q15 hypothetical protein DKFZp313G1735 LOC285601 5q15 seven transmembrane helix receptor LOC285601 LOC317671 5q15 LOC317671 SPATA9 5q15 spermatogenesis associated 9 RHOBTB3 5q21.2 Rho-related BTB domain containing 3 GLRX 5q14 glutaredoxin (thioltransferase) FIS 5q15 FIS ELL2 1q21-q25 elongation factor, RNA polymerase II, 2 PCSK1 5q15-q21 proprotein convertase subtilisin/kexin type 1 LOC389311 5 LOC389311 CAST 5q15-q21 calpastatin ARTS-1 5q15 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator LRAP 16 leukocyte-derived arginine aminopeptidase FLJ39485 5q15 hypothetical protein FLJ39485 LNPEP 5q21 leucyl/cystinyl aminopeptidase FLJ25534 5q15 hypothetical protein FLJ25534 RIOK2 5q14 RIO kinase 2 (yeast) LOC391812 5 similar to Dermatomyositis associated with cancer putative autoantigen-1 (DACA-1) LOC391813 5 similar to Zinc finger DHHC domain containing protein 3 (Zinc finger protein 373) (DHHC1 protein) LOC389312 5 similar to Proteasome activator complex subunit 2 (Proteasome activator 28-beta subunit) (PA28beta) (PA28b) (Activator of multicatalytic protease subunit 2) (11S regulator complex beta subunit) (REG-beta) LOC391814 5 similar to cytoplasmic beta-actin MRPS35P2 5q15 mitochondrial ribosomal protein S35 pseudogene 2 LOC285703 5q21.1 similar to C-terminal binding protein 2 isoform 2; ribeye LOC391815 5 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) FLJ90406 CHD1 5q15-q21 chromodomain helicase DNA binding protein 1
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 5566 - 611 - 2002 1242610
Type ubiquitous
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   moderately
Endocrinepancreas   moderately
Reproductivefemale systemovary  highly
 male systemtestis  moderately
cell lineage
cell lines
physiological period fetal
Text fetal tissues, particularly brain, heart, and lung
  • a GTPase (guanosine triphosphatase) domain
  • a proline rich region
  • a tandem of two BTB (Broad-Complex, Tramtrack, and Bric a brac) domains
  • a prenylation motif
  • a C-terminal region of unknown function
  • Rho GTPase family
  • RHOBTB subfamily
  • CATEGORY enzyme , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
  • RAB9A Effector and Localized to the Golgi (Espinosa 2009)
  • co-localization between the HTR7 receptor and RHOBTB3 at the plasma membrane and in the endoplasmic reticulum
  • basic FUNCTION
  • only RhoBTB with a prenylation motif, associates with vesicles that are frequently found in the vicinity of microtubules, suggesting a participation in some aspects of vesicle trafficking (Berthold 2008)
  • tumor suppressors that might function as adaptors of CUL3-dependent ubiquitin ligase complexes (Berthold 2008)
  • play a part in the carcinogenic process through a mechanism that involves the decreased or abolished expression of the corresponding genes, or more rarely, mutations that result in impaired functioning of the protein, presumably leading to the accumulation of RhoBTB substrates and alterations of the cellular homeostasis (Berthold 2008)
  • RAB9A-regulated ATPase that may function in vesicle docking by uncoating transport vesicles at their target (Espinosa 2009)
  • regulates the S/G2 transition of the cell cycle by targeting CCNE for ubiquitylation
    a component
  • RHOBTB2 and RHOBTB3 are capable of homo and heterodimerizing through the BTB domain region (Berthold 2008)
  • on the Golgi, RHOBTB3 bound CCNE as part of a Cullin3 (CUL3)-dependent RING-E3 ubiquitin ligase complex comprised of RHOBTB3, CUL3, and RBX1
    small molecule
  • interact with CUL3 (interaction requires the N-terminal region of CUL3 and the first BTB domain of RhoBTB) (Berthold 2008)
  • binds directly to RAB9A GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network (Espinosa 2009)
  • interacts with PLIN3 on membranes, we propose that it may function to release this cargo selection protein from vesicles to permit their efficient docking and fusion at the Golgi (Espinosa 2009)
  • RHOBTB3 is a new interaction partner of the HTR7 receptor, and strongly inhibits proteasomal degradation of HTR7 receptor
  • RHOBTB3, a Golgi-associated, Rho-related ATPase, regulates the S/G2 transition of the cell cycle by targeting CCNE for ubiquitylation
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    arrested cells in S phase, triggered Golgi fragmentation, and elevated CCNE levels
    Variant & Polymorphism
    Candidate gene
    Therapy target