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FLASH GENE
Symbol RHOB contributors: mct/npt/pgu - updated : 18-09-2013
HGNC name ras homolog gene family, member B
HGNC id 668
Location 2p24.1      Physical location : 20.646.834 - 20.649.200
Synonym name
  • oncogene RHO H6
  • aplysia RAS-related homolog 6
  • ras homolog gene family, member B
  • Synonym symbol(s) ARH6, ARHB, RHOH6, H6, MST081, MSTP081
    DNA
    TYPE functioning gene
    STRUCTURE 2.37 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2384 - 196 - 2008 18524772
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP
    HOMOLOGY
    interspecies ortholog to murine Rhob
    ortholog to rattus rhob
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rho family
  • CATEGORY regulatory , protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text also detected at the late endosomal membrane (geranylgeranylated form)and the nuclear margin
    basic FUNCTION
  • coordinated assembly of focal adhesions and stress fibers
  • linking growth factor receptors to the activation of actin polymerization
  • playing a critical role in muscle differentiation
  • mediating the distinct actin cytoskeleton
  • changes required for both cellular motility and cell-cell adhesion
  • small GTPase implicated in cytoskeletal organization, EGF receptor trafficking and cell transformation
  • implicated as a novel intermediate in critical signaling pathways
  • play a role in cell survival as inhibiting its expression leads to increase in cell apoptosis and a relocalization of focal adhesion kinase
  • with RHOA, and RAC1, are involved in the establishment of the migratory and invasive phenotype of tumour cells that have CDH1 mutation
  • major regulator of CDH1-mediated cell
  • cell adhesion and are involved in the induction, propagation and expansion of cell
    cell contacts
  • implicated in cofilin regulation and dendritic and spine morphology, highlighting its importance in synaptic plasticity at a structural and functional level
  • novel RHOB-dependent endosomal trafficking pathway that integrates RTK endocytosis with CDC42/RAC1 localization and cell movement
  • neuronal RHOB implicated in caspase 3 activation and the initial stages of programmed cell death(
  • mediates adaptational changes to acute hypoxia in the vasculature, but its continual activation by chronic hypoxia can accentuate vascular remodeling to promote development of pulmonary hypertension
  • contributes to directional cell migration by regulating ITGB1 integrin surface levels and activity, thereby stabilizing lamellipodial protrusions
  • RHOA, RHOB and RHOC all have the potential to interact with the same downstream effectors, yet they have substantially different effects on cell shape and migratory properties
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • putative regulator of myogenin and MEF25 genes
  • ARGGEF3
  • nteravcting wth ECT2 and NET1 (nuclear guanine nucleotide exchange factors ECT2 and NET1 regulate RHOB-mediated cell death after DNA damage)
  • IQGAP1 interacts directly with GTP-bound, prenylated RHOA and RHOC, but not with RHOB
  • ARHGEF3 activates RHOA and RHOB, but not RHOC, although their GTPase sequences are highly conserved
  • aberrant upregulation of SMURF1 promotes tumorigenesis by excessively targeting RHOB for degradation
  • cell & other
    REGULATION
    activated by inhibition of CSNK1A1 that activates RHOB and promotes RHOB dependent actin fiber formation and EGFR level
    hypoxia, and regulates neoplastic growth and vasoconstriction
    Other transcriptional regulation by the nuclear transcription factor PPARgamma is responsible for the induction of CDKN1A mRNA and protein
    monophosphorylated by CSNK1A1, in its C-terminal end, on serine 185
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to osteoarthritis
    Variant & Polymorphism SNP significant associations between 5' SNPs and osteoarthritis that hint at regulatory functions
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinethyroid
    target for therapeutic intervention in anaplastic thyroid cancer
    neurology  
    may represent an attractive target for therapeutic intervention in conditions involving elevated caspase 3 activity in the central nervous system
    ANIMAL & CELL MODELS