| protein
| putative regulator of myogenin and MEF25 genes |
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rhotekin ( |
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GDP/GTP exchange factor, RhoGEF ( |
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p190 ( |
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protein-kinase C-related kinase 1, PRK1 ( |
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Kinectin, mDia2, the guanine nucleotide exchange factor mNET1, beta2 and Skn7 ( |
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caveolin-1, CAV1 ( |
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DGKtheta ( |
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trio guanine nucleotide exchange factor ( |
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phospholipase D1, PLD1 ( |
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RhoA-associated kinase-2, ROCK-2 ( |
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small G-protein dissociation stimulator, smgGDS ( |
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G-protein betagamma, Gbetagamma and phospholipase C-gamma1, PLC-gamma1 ( |
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Rhophilin-2, RHPN2 ( |
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exchange factor found in platelets and leukemic and neuronal tissues, XPLN ( |
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heat shock protein HSP72 ( |
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inositol 1,4,5-trisphosphate receptor, type 3, IP3R and transient receptor potential channel-1, TRPC1 ( |
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Myosin phosphatase-Rho interacting protein, M-RIP ( |
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transiently-expressed axonal glycoprotein, TAX ( |
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differentially expressed in FDCP 6 homolog (mouse), DEF6 ( |
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MYH9 and PLEKHG6 |
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full activation of RHOA required ECT2 as well as PKP4 indicating that these two proteins act in conjunction to regulate RHOA during cytokinesis |
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ANLN is a scaffold protein that links RHOA, actin, and myosin during cytokinesis |
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CGNL1 is a regulator of the activity of two small GTPases, RAC1 and RHOA, through the functional interaction with their respective activators, TIAM1 and ARHGEF2 |
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ARHGEF10 |
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RHOA and RHOC are both required for the ROCK2-dependent promotion of centrosome duplication |
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interacting with SMURF1 (C2 domain of SMURF1 is necessary and sufficient for binding RHOA, and therefore is crucial for targeting RhHOA for ubiquitination) |
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ARHGEF3 is a regulator of transferrin uptake in erythroid cells, through activation of RHOA |
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ARHGAP18 is one of the crucial factors for the regulation of RHOA for the control of cell shape, spreading, and migration |
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CIT maintains correct RHOA localization at the cleavage site, which is necessary for proper RHOA activity and contractile ring dynamics in cytokinesis |
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novel role of RPKD1, PRKD2 as a regulator of RHOA activity and actin stress fiber formation through phosphorylation of rhotekin |
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OPHN1 exhibits strong GTPase-stimulating activity towards RHOA, CDC42, and RAC1 and regulates cell adhesion and spreading |
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SLIT2 regulates the dispersal of oligodendrocyte precursor cells through FYN and RHOA signaling |
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RHOA activity polarizes around SYTL1-containing secretory granules, suggesting that it may control directionality of granule movement |
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AGAP1 and AGAP2 can bind to RHOA |
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INPPL1 interacts with RHOA in a GTP-dependent manner (RHOA associates with INPPL1 to regulate cell polarization and migration) |
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involvement of RHOA and ROCK1 in F11R relocalization |
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RYK is required for Wnt/planar cell polarity signaling during mammalian development and signals via VANGL2 and RHOA |
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IQGAP1 interacts directly with GTP-bound, prenylated RHOA and RHOC, but not with RHOB |
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direct binding of RHOA and C to the C-terminal half of IQGAP1, which contains the GAP-related domain required for CDC42 and RAC1 binding |
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ARHGEF3 activates RHOA and RHOB, but not RHOC, although their GTPase sequences are highly conserved |
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ARHGAP21 presented GAP activity for RHOA and RHOC and induced changes in cell morphology |
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deregulation of RHOA activation in the absence of SLC3A2 is also a result of impaired SLC3A2-dependent amino acid transports |
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stimulates the production of FN1 by podocytes, specifically testing the role of nuclear factor of activated T cells (NFATC1) |
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NFATC1 mediates RHOA-induced FN1 upregulation in glomerular podocytes |
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CES1 had a clear impact not only on the methylation status of RHOA but also RHOA activation and cell morphology |
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function of PLEKHG5 is mediated by the selective activation of the RHOA downstream effector DIAPH1 (PMID |
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ARHGEF18 is a key regulator of RHOA-ROCK2 signaling that is crucial for maintenance of polarity in the vertebrate retinal epithelium |
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XIAP and, to a lesser extent, BIRC2 were found to directly interact with RHOA independently of the RHOA activation status |
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STARD13 is a RHO-GAP that specifically inhibits the function of RHOA and CDC42 |
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regulation of desmosomal adhesion by RHOA- and PRKC-mediated ADD1 phosphorylation in keratinocytes |
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CGN and CGNL1 control RHOA activation in epithelial cells by interacting with RHOA guanidine exchange factors |
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RACGAP1 promoted the activations of RHOA, PTK2, PXN and triggered focal adhesion formation and cytoskeletal rearrangement |
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is a GTPase-activating protein (GAP) that inactivates ARF6 and RHOA small GTPases |
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GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA |
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interplay between ARHGEF40 and KRT8/KRT18 filaments plays a crucial role in tensile force-induced RHOA activation and consequent actin cytoskeletal reinforcement |
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regulation of RHOA activation through ARHGEF18 is important for tissue morphogenesis and migration and in the assembly and maintenance of cell-cell junction |
