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FLASH GENE

Symbol

RGS9BP

contributors: mct - updated : 10-03-2016

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PERRS prolonged electroretinal response suppression
Location	19q13.11      Physical location : 33.166.312 - 33.169.206
Genatlas name	regulator of G protein signaling 9-binding protein
Synonym name	RGS9.1 anchor protein
Synonym symbol(s)	R9P, FLJ5744

DNA

TYPE	functioning gene
STRUCTURE	0.00 kb     1 Exon(s)

text structure

intron less

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text

one

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

transmembrane C terminal helix anchor

HOMOLOGY

Homologene

FAMILY

CATEGORY

signaling neurotransmitter

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	binding to the N-terminal domain of RGS9-1, and anchoring it to the disk membrane via a C-terminal transmembrane helix
	in photoreceptors, RGS9BP is required for proteolytic stability of the entire regulator of G protein signaling complex

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

RGS11 forms complexes with the atypical G protein beta subunit, GNB5, and transmembrane protein RGS9BP

INTERACTION

DNA

RNA

small molecule

protein

RGS9BP is required for stable expression of RGS11-GNB5 in ON-bipolar cell dendrites

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PERRS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS