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FLASH GENE
Symbol RGS8 contributors: mct - updated : 21-12-2011
HGNC name regulator of G-protein signaling 8
HGNC id 16810
Location 1q25.3      Physical location : 182.615.791 - 182.642.067
Synonym symbol(s) MGC119067, MGC119068, MGC119069
DNA
TYPE functioning gene
STRUCTURE 26.28 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D1S466 - D1S2618 - RGS8 - C1orf13 - D1S2442 - C1orf14 - LAMC1 - LAMC2 - C1orf15 - C1orf16 - C1orf18 - C1orf17 - D1S158 - C1orf19 - C1orf20 - C1orf21 - D1S2701 - C1orf22 - C1orf23 - D1S2127 - C1orf24 - D1S240 - C1orf25 - C1orf26 - D1S254 - D1S444 - D1S191 - D1S2948 - CACP - C21orf27 - D1S1599 - D1S202 - D1S1642 - B3GALT2 - qter
Authors Sood (01)
Physical map
KIAA1614 1q25.1 KIAA1614 protein LOC391142 1 hypothetical gene supported by AJ249778; NM_001531 STX6 1p36 syntaxin 6 MR1 1q25.3 major histocompatibility complex, class I-related IER5 1q25.1 immediate early response 5 LOC284646 1q25.1 hypothetical gene supported by BC039493 CACNA1E 1q25-q31 calcium channel, voltage-dependent, alpha 1E subunit LOC127665 1q25.2 similar to zinc finger protein 135 (clone pHZ-17); zinc finger protein 61 LOC388718 1 similar to Protein translation factor SUI1 homolog (Sui1iso1) GLUL 1q31 glutamate-ammonia ligase (glutamine synthase) HE9 1q25.2 putative membrane protein HE9 LOC388719 1 hypothetical gene supported by AF508909 LOC127671 1q25.2 similar to CE9 protein RGSL2 1q25.2 regulator of G-protein signalling like 2 RGSL1  regulator of G-protein signalling like 1 RNASEL 1q25 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) RGS16 1q25-q31 regulator of G-protein signalling 16 RGS8 1q25-q31 regulator of G-protein signalling 8 NPL 1q25 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) DHX9 1q25 DEAH (Asp-Glu-Ala-His) box polypeptide 9 C1orf14 1q25-q31 chromosome 1 open reading frame 14 LOC391143 1 similar to natural cytotoxicity triggering receptor 1; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocyte antigen 94 (mouse) homolog (activating NK-receptor ; NK-p46); lymphocyte antigen 94 homolog, a LOC343326 1q25.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LAMC1 1q31 laminin, gamma 1 (formerly LAMB2) LAMC2 1q25-q31 laminin, gamma 2 NMNAT2 1q25-q31 nicotinamide nucleotide adenylyltransferase 2 C1orf16 1q25-q31 chromosome 1 open reading frame 16 NCF2 1q25 neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) ARPC5 1q25.2 actin related protein 2/3 complex, subunit 5, 16kDa RGL 1q25.2 actin related protein 2/3 complex, subunit 5, 16kDa C1orf17 1q25-q31 chromosome 1 open reading frame 17 C1orf19 1q25-q31 chromosome 1 open reading frame 19
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 polyA site 912 20.8 180 . brain-specific 2002 12110731
  • 9 aa in the N terminus of RGS8 contribute to the function to inhibit Gq-coupled signaling in a receptor type-specific manner
  • 6 - 783 22.8 198 - 2002 12110731
    - splicing - - - - 2002 12110731
  • regulatory function of RGS8S is especially diminished on Gq-coupled responses
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MPRR at the N-terminus, that is the PPP1R9B-binding site
  • HOMOLOGY
    interspecies ortholog to rattus Rgs8
    Homologene
    FAMILY
  • regulator of G protein family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a role in suppression of Gq signaling in a receptor type-specific manner (diminished role for RGS8S)
  • indirect binding of RGS8 to the CHRM1 through PPP1R9B for an efficient regulatory function
  • recruitment of RGS8 to the receptor differentially affects the function of RGS8 among receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms
  • PPP1R9B is a RGS8-interacting protein (CHRM1 and PPP1R9B compete for binding to RGS8)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS