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FLASH GENE
Symbol RGS7BP contributors: mct - updated : 09-03-2016
HGNC name regulator of G-protein signalling 7 binding protein
HGNC id 23271
Location 5q12.3      Physical location : 63.802.451 - 63.908.119
Synonym symbol(s) R7BP
DNA
TYPE functioning gene
STRUCTURE 105.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 neuroendocrinepituitary  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to R9AP which was previously found to interact with RGS9 in photoreceptors
Homologene
FAMILY syntaxin subfamily
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • involved in the augmentation of the function of the RGS7/GNB5 complexes, by a palmitoylation-regulated plasma membrane-targeting mechanism
  • RGS7, in cooperation with its binding partner RGS7BP, regulates GABABR-GIRK signaling in hippocampal pyramidal neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forms a tight complex with RGS9 (this binding occurs via the N-terminal DEP domain of RGS9) in striatal neurons
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neuronal protein interacting with RGS proteins of the R7 family
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS