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FLASH GENE
Symbol RGS5 contributors: np - updated : 19-01-2007
HGNC name regulator of G-protein signaling 5
HGNC id 10001
Location 1q23.3      Physical location : 163.112.088 - 163.172.963
Synonym symbol(s) RP11-430G6.2, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129
DNA
TYPE functioning gene
STRUCTURE 60.88 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 5426 - 73 highly expressed in the ciliary body and trabecular meshwork, in the eye, and in the kidney, brain, spleen, skeletal muscle and small intestine, but was not detectable in the liver, lung, heart 2005 15670159
  • also called RGS5s
  • 108 amino acid N-terminal deletion
  • may contain functional domains that compete with RGS5 in the regulation of the Galphaq coupled AT1 and FP receptors
  • may play a critical role in the regulation of intracellular signaling pathways
  • 5 - 5927 - 181 - 2005 15670159
  • present in both membrane and cytosolic fractions
  • N-terminal may be important for protein translocation to the cell membrane
  • inhibited the Ca2+ signaling initiated by activation of Galphaq coupled angiotensin II receptors (AT1) and prostaglandin FP receptors
  • EXPRESSION
    Rna function high levels of RGS5 mRNA in heart tissue
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
     liver   lowly
    Endocrineadrenal gland   highly
    Nervousnerve   highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel highly Homo sapiens
    Muscularstriatumskeletal highly Homo sapiens
    Muscularstriatumcardiac highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal (1-33) playing a role in targeting this protein to membranes, and not essential for exerting activities
  • a RGS domain with three conserved motifs GH1, GH2, GH3,
  • a C terminal coiled-coil domain
  • one regulator of G protein signaling domain
  • HOMOLOGY
    interspecies homolog to yeast SST2
    Homologene
    FAMILY
    CATEGORY regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text strongly expressed in vessels during angiogenesis
    basic FUNCTION
  • inhibiting signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
  • involved in the induction of endothelial apoptosis, antagonizing the angiogenic effect of VEGF by increasing the activation of p38 signaling
  • crucial component of the signaling pathway involved in cardiac remodeling and heart failure
  • its cardiac constitutive expression protects against cardiac hypertrophy and fibrosis by blocking MEK-ERK1/2 signaling
  • role in maintaining cardiac contractility and in reducing fibrosis in response to hypertrophic stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text promoting chondrocyte differentiation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to GNAI1 and GNAO1, but not to GNAS
  • cell & other
    REGULATION
    induced by HIF1-dependent hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in clear cell renal carcinoma with good outcome
    Susceptibility to essential hypertension
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • could be an important target for apoptotic therapy
  • treatment of cardiac hypertrophy through targeting of the RGS5 signaling pathway
  • ANIMAL & CELL MODELS