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FLASH GENE
Symbol RGS4 contributors: mct - updated : 19-12-2016
HGNC name regulator of G-protein signaling 4
HGNC id 10000
Corresponding disease
SCZD9 schizophrenia 9
Location 1q23.3      Physical location : 163.038.395 - 163.046.591
Synonym symbol(s) RGP4, MGC60244, DKFZp761F1924, MGC2124
DNA
TYPE functioning gene
STRUCTURE 8.23 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   cAMP
text structure
  • promoter region of RGS4-1 (between TSS1 and TSS2) contains a CREBP1 (cAMP-responsive element binding protein 1) binding site, -150 to -157 bp upstream of TSS1 (transcription start site 1)
  • promoter of RGS4-2 (between TSS2 and TSS3) contains a steroidogenic factor 1 (SF1) binding site
  • promoter of RGS4-3 (upstream of TSS3) contains several candidate transcription factor binding sites such as CEBPB (CCAAT/enhancer binding protein beta), and also contains three SRY (sex-determining region y, or testis-determining factor, TDF) binding sites
  • promoter region for RGS4-5 also contains candidate transcriptional factor binding motifs, including ZF35
  • MAPPING cloned Y linked N status provisional
    Physical map
    SDHC 1q21 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa LOC257177 1q23.1 similar to hypothetical protein MGC20470 LOC148430 1q23.1 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC388709 1 LOC388709 LOC388710 1 LOC388710 FCGR2A 1q23 Fc fragment of IgG, low affinity IIa, receptor for (CD32) HSPA6 1q heat shock 70kDa protein 6 (HSP70B') FCGR3A 1q23 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) FCGR3B 1q23 Fc fragment of IgG, low affinity IIIb, receptor for (CD16) FCGR2B 1q23 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FREB 1q23.1 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FLJ31052 1q23.1 hypothetical protein FLJ31052 DUSP12 1q22 dual specificity phosphatase 12 ATF6 1q22-q23 activating transcription factor 6 DKFZP586L151 1q23.1 DKFZP586L151 protein CAPON 1q23.1-q23.2 C-terminal PDZ domain ligand of neuronal nitric oxide synthase LOC284680 1q23.2 hypothetical protein LOC284680 EAT2 1q22 Homo sapiens SH2 domain-containing molecule EAT2 (EAT2), mRNA. KIS 1q23.2 kinase interacting with leukemia-associated gene (stathmin) UAP1 1q23.1 UDP-N-acteylglucosamine pyrophosphorylase 1 DDR2 1q21-q23 discoidin domain receptor family, member 2 HSD17B7 17p11.2 hydroxysteroid (17-beta) dehydrogenase 7 MGC48998 1q23.2 hypothetical protein MGC48998 RGS4 1q23.2 regulator of G-protein signalling 4 RGS5 1q23 regulator of G-protein signalling 5 CDCA1 1q23.1 cell division cycle associated 1 LOC388711 1 hypothetical gene supported by BC037210; NM_005342 PBX1 1q23 pre-B-cell leukemia transcription factor 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3480 - 302 . in the cerebral cortex but not in the cerebellum . in the adult brain as well as prostate, spinal cord, adrenal gland, trachea, and testis, and it has lower expression in other tissues 2007 17707117
    5 - 3055 - 187 . in the cerebral cortex but not in the cerebellum . low levels of expression in the fetal brain, spinal cord, heart and prostate and barely detectable expression in several other tissues 2007 17707117
    4 - 2924 - 93 ubiquitous 2007 17707117
    5 - 980 - 487 . ubiquitous . highest in adult human brain, and moderate expression in spinal cord, testis, cerebellum and adrenal gland 2007 17707117
    5 - 3371 - 205 . in the cerebral cortex but not in the cerebellum . mainly expressed in the brain, spinal cord and prostate. It also has low expression in thyroid, trachea, uterus, fetal brain, heart and kidney 2007 17707117
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   lowly
    Nervousbrainforebraincerebral cortex highly Homo sapiens
     brainbasal nucleiputamen highly Homo sapiens
     brainbasal nucleicaudate nucleus highly Homo sapiens
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one RGS domain
  • amphipatic helix
  • HOMOLOGY
    interspecies homolog to murine Rgs4
    intraspecies homolog to RGS1
    Homologene
    FAMILY
  • regulator of G protein family
  • regulator of G protein subfamily R4
  • CATEGORY tumor suppressor , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • negatively regulating signaling upstream or at the level of the heterotrimeric G protein
  • regulates G proteins that gate potassium channels and Ca2+ channel
  • has GTPase-activating protein (GAP) activity, which inhibits G-protein coupled receptor signaling by deactivating G-proteins
  • suppressor of breast cancer migration and invasion, important steps of metastatic cascades
  • plays a key role in G protein coupling selectivity and signaling of the OPRMs and OPRDs
  • play an important role in regulating beta-cell function
  • acts as a GTPase accelerating protein to modulate OPRM1 and OPRD1 signaling
  • opioid agonist-induced reduction in RGS4 occurs via the ubiquitin-proteasome pathway and may contribute to the maintenance of cell homeostasis in the morphine-dependent state
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text inhibiting chondrocyte differentiation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the C-termini of mu- and delta-opioid receptors
  • LMX1A is an activator of RGS4 and GRB10 and is responsible for the correct specification of rostral and medial mesodiencephalic dopamine (mdDA) neurons
  • RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate OPRK1 signaling
  • cell & other
    REGULATION
    activated by co-expression of DHHC acyltransferases (DHHC3 or DHHC7), but not their acyltransferase-inactive mutants, increased expression levels of RGS4
    repressed by opioid agonists that reduce levels of RGS4 protein by an action to promote degradation
    ASSOCIATED DISORDERS
    corresponding disease(s) SCZD9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma cells (Wang 2009)
    Susceptibility to schizophrenia (SCZD9)
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    may represent a potential target to promote insulin release for therapeutic purposes in type 2 diabetes
    ANIMAL & CELL MODELS