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FLASH GENE
Symbol RGS2 contributors: mct/npt/pgu - updated : 19-12-2017
HGNC name regulator of G-protein signaling 2, 24kDa
HGNC id 9998
Location 1q31.2      Physical location : 192.778.168 - 192.781.406
Synonym name
  • G0 to G1 switch regulatory 8, 24kD
  • cell growth-inhibiting protein 31
  • Synonym symbol(s) G0S8, RGS-2
    DNA
    TYPE functioning gene
    STRUCTURE 3.23 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • promoter region of RGS2 contained a binding sequence of HSF1, which is an activator of the heat shock protein gene, and was inducibly bound by stress-activated HSF1
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1375 - 211 - 2001 11234015
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Nervousbrain    
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • internal sequence within the N-terminal region of RGS2 (amino acids 28-80) was involved in the RGS2 modulation of MCHR1 activity
  • basic helix-loop-helix (HLH) protein
  • several potential phosphorylation sites
  • a C terminal RGS domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to C.elegans EGL-10
    homolog to yeast SST2
    Homologene
    FAMILY
  • regulator of G-protein signaling family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • negative regulator of G-protein signaling 2, functioning as GTPase-activating protein for G protein alpha i and q subunits, cell cycle, switch regulatory gene G0 to G1 phosphoprotein
  • regulating signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase II (ADCY3)
  • regulator of angiotensin II (Ang II) signaling
  • modulates dopamine receptor signal transduction
  • role for RGS2 in the control of protein synthesis that is independent of its established RGS domain function
  • negative regulator of Galphaq protein signalling, which mediates the action of several vasoconstrictors
  • potential role of RGS2 in regulation of enzymes involved in antioxidant defense namely glyoxalase-1 and glutathione reductase-1 via activation of MAPK14 and PKC pathways in an Sp1 dependent manner
  • having additional G protein-independent functions including control of ion channel currents, microtubule polymerization, and protein synthesis
  • stress-dependent RGS2 upregulation acts to suppress protein synthesis
  • RGS2 functions on a daily basis to negatively modulate melatonin production
  • is a potent negative regulator of Gq protein signals including the angiotensin II (AGT)/AGTR1 signal, which plays a critical role in the progression of fibrosis
  • RGS2 is integral for ARRB-mediated D2R internalization
  • both RGS2 and RGS4 play positive roles during adipogenesis but opposing roles during osteogenesis, with RGS2 is a positive regulator and RGS4 is a negative regulator
  • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with PRKG1 (attenuating receptor- mediated vascular cotraction)
  • TRPV6-associated protein
  • efficient regulator of MCHR1-mediated calcium signaling exclusively via the Galphaq-dependent pathway
  • RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms
  • RGS2 inhibits STAT3-mediated NOX1 transcription, and can itself be repressed by TLR2
  • RGS2 is an important factor in the latent and EIF2A phosphorylation-independent inhibition of protein synthesis following stress
  • UTS2R activation stimulates RGS2 recruitment to glomerular mesangial cells (GMCs) plasma membrane as a negative feedback mechanism to regulate UTS2R signaling
  • RGS2-deficient vascular smooth muscle cells (VSMC) exhibit higher rates of proliferation and coordinate plasticity of Ca(2+)-handling mechanisms in response to PDGF stimulation
  • RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate OPRK1 signaling
  • cell & other
    REGULATION
    activated by PRKG1A
    induced by oxidative stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    contributes to resistance to antihypertensive agents through poor negative feedback on the effects of aldosterone and of other vasoactive agents
    constitutional       loss of function
    decreases Uterine artery blood flow (UABF) by increasing myogenic tone at least partly through prolonged G protein activation
    constitutional       loss of function
    impairs renal function and autoregulation by increasing renal vascular resistance and reducing renal blood flow
    Susceptibility
  • to Panic disorder (PD)
  • to antipsychotic-induced parkinsonism (AIP)
  • Variant & Polymorphism SNP , other
  • association of three-SNP haplotyp with PD in a Japanese population
  • protective role of a functional polymorphism in the 3prime-untranslated region
  • Candidate gene
    Marker
  • novel Alzheimer disease (AD) biomarker (alongside other genes) toward early AD detection and future disease modifying therapeutics
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativehuntington chorea
    RGS2 downregulation is a novel compensatory response in HD neurons,suggesting that RGS2 inhibition might be considered as an innovative target for neuroprotective drug development
    miscelleaneoushypertension 
    cardiotonic steroids (CTSs)-induced increases in RGS2 protein levels and function might modify several deleterious mechanisms in hypertension and heart failure
    ANIMAL & CELL MODELS
    Rgs2(-/-) mice are hypertensive and prone to heart failure