basic FUNCTION
| negative regulator of G-protein signaling 2, functioning as GTPase-activating protein for G protein alpha i and q subunits, cell cycle, switch regulatory gene G0 to G1 phosphoprotein |
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regulating signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase II (ADCY3) |
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regulator of angiotensin II (Ang II) signaling |
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modulates dopamine receptor signal transduction |
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role for RGS2 in the control of protein synthesis that is independent of its established RGS domain function |
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negative regulator of Galphaq protein signalling, which mediates the action of several vasoconstrictors |
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potential role of RGS2 in regulation of enzymes involved in antioxidant defense namely glyoxalase-1 and glutathione reductase-1 via activation of MAPK14 and PKC pathways in an Sp1 dependent manner |
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having additional G protein-independent functions including control of ion channel currents, microtubule polymerization, and protein synthesis |
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stress-dependent RGS2 upregulation acts to suppress protein synthesis |
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RGS2 functions on a daily basis to negatively modulate melatonin production |
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is a potent negative regulator of Gq protein signals including the angiotensin II (AGT)/AGTR1 signal, which plays a critical role in the progression of fibrosis |
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RGS2 is integral for ARRB-mediated D2R internalization |
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both RGS2 and RGS4 play positive roles during adipogenesis but opposing roles during osteogenesis, with RGS2 is a positive regulator and RGS4 is a negative regulator |