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FLASH GENE
Symbol RGS19 contributors: mct - updated : 14-02-2011
HGNC name regulator of G-protein signaling 19
HGNC id 13735
Location 20q13.33      Physical location : 62.704.536 - 62.711.324
Synonym name
  • G alpha interacting protein
  • guanine nucleotide binding protein alpha inhibiting
  • polypeptide 3 interacting protein
  • Synonym symbol(s) GAIP, RGSGAIP, GNAI3IP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text adjacent to and in an opposite orientation to the opioid-receptor-like receptor 1 (ORL1) gene
    STRUCTURE 6.79 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure two different promoters are alternatively employed to start the transcription of two 5' distinctive mRNAs
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1593 24.5 217 - 2003 12507475
    6 - 1493 24.5 217 - 2003 12507475
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • N-terminal domain plays a crucial role in its receptor preference
  • one regulator of G protein signaling domain
  • multiple potential phosphorylation sites
  • cysteine string
  • C-terminal PDZ-binding motif
  • HOMOLOGY
    Homologene
    FAMILY
  • regulator of G-protein signaling family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • inhibiting signal transduction by increasing GTP activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
  • negatively regulate the signaling of many G protein-coupled receptors, including the opioid receptors
  • complex role for RGS19 in regulating the ability of WNT3A to signal to the level of beta-catenin and gene transcription
  • implicated in growth factor signaling through binding to GAIP-interacting protein C-terminus (GIPC1) via its C-terminal PDZ-binding motif
  • in addition to acting as a GAP, is able to stimulate cell proliferation in a GIPC1-dependent manner
  • influenced cardiac development and had negative effects on heart function
  • negatively affects and plays an important role in cardiac development and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with G protein, GAI3
  • recruited by GIPC1 to attenuate dopamine D2 receptor signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Rgs19 TG mice revealed abnormal ventricular development, including ventricular septal defect, a thin ventricular wall, and ventricular noncompaction