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FLASH GENE
Symbol RGS18 contributors: mct/npt - updated : 20-09-2016
HGNC name regulator of G-protein signaling 18
HGNC id 14261
Location 1q31.2      Physical location : 192.127.591 - 192.154.943
Synonym name regulator of G-protein signaling 13
Synonym symbol(s) RGS13
DNA
TYPE functioning gene
STRUCTURE 28.71 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DBCCR1L 1q25.3 DBCCR1-like RGS18 1q31,2 regulator of G-protein signalling 18 LOC220672 1q31.1 similar to ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) (HuHP68) LOC164036 1q31.1 similar to implantation-related RGS2-like protein RGS1 1q31 regulator of G-protein signalling 1 RGS13 1q25-3 regulator of G-protein signalling 13 LOC388720 1 similar to bA92K2.2 (similar to ubiquitin) RGS2 1q31 regulator of G-protein signalling 2, 24kDa LOC388721 1 LOC388721 LOC391146 1 similar to zinc finger protein 12 UCHL5 1q32 ubiquitin carboxyl-terminal hydrolase L5 SSA2 1q32 Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS-A/Ro) GLRX2 1q31.2-q31.3 glutaredoxin 2 C1orf28 1q25-q31 chromosome 1 open reading frame 28 B3GALT2 1q31 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 LOC343448 1q31.1 similar to elongation factor 1 alpha
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2158 27.45 235 - 2016 26567214
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
 spleen   specific
Digestiveliver    
Lymphoid/Immunethymus   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte Homo sapiens
Blood/Hematopoieticplatelet Homo sapiens
Blood/Hematopoieticprogenitor cell Homo sapiens
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • amphipathic helix
  • one RGS domain
  • HOMOLOGY
    interspecies homolog to murine Rgs18
    Homologene
    FAMILY
  • regulator of G protein family
  • subfamily R4
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in the regulation of central nervous system function via modulation of signaling by G-protein coupled receptors
  • acts as a negative regulator of the acidosis-induced osteoclastogenic GPR68/NFATC1 signaling pathway, and TNFSF11 stimulates osteoclastogenesis by inhibiting expression of RGS18
  • integrates activating and inhibitory signaling in platelets
  • regulates megakaryopoiesis but also having an unexpected role in ciliogenesis, at least in lower vertebrates, via interference with Wnt signaling
  • plays a significant role in hemostasis and thrombosis, through its critical and direct role in modulating platelet function
  • dual role of RGS18 in reciprocally regulating divergent lineages could exemplify generic mechanisms characteristic of multiple family members in different contexts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a GTPase-activating protein for the GNAQ and GNAI1 subunits of heterotrimeric G-proteins that turns off signaling by G-protein coupled receptors
  • YWHAG binds to phosphorylated serines 49 and 218 of RGS18
  • GFI1B stringently represses RGS18 expression in erythroid cells, whereas, during megakaryocytic differentiation, declining GFI1B levels facilitate a robust induction of RGS18
  • cell & other
    REGULATION
    Other regulated by binding to the adaptor protein 14-3-3 via phosphorylated serine residues S49 and S218 on RGS18
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    produced a gain of function phenotype in platelets, with increased thrombus formation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rgs18 -/- mice presented a mild thrombocytopenia, accompanied with a marked deficit in MK number in the bone marrow