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FLASH GENE
Symbol RGS11 contributors: mct - updated : 09-03-2016
HGNC name regulator of G-protein signaling 11
HGNC id 9993
Location 16p13.3      Physical location : 318.309 - 325.914
Synonym symbol(s) RS11
DNA
TYPE functioning gene
STRUCTURE 7.64 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390662 16 similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; DEAD/H box-11 (CHL1-related helicase gene-1); yeast CHL1 homolog CXYorf1P 16p13.3 pseudogene of CXYorf1 POLR3K 16p13.3 polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa C16orf33 16p13.3 chromosome 16 open reading frame 33 RHBDF1 16p13.3 rhomboid family 1 (Drosophila) MPG 16p13.3 N-methylpurine-DNA glycosylase C16orf35 16p13.3 chromosome 16 open reading frame 35 HBZ 16p13.3 hemoglobin, zeta HBZP 16p13.3 hemoglobin, zeta pseudogene HBAP2 16p13.3 hemoglobin, alpha pseudogene 2 HBAP1 16p13.3 hemoglobin, alpha pseudogene 1 HBA2 16p13.3 hemoglobin, alpha 2 HBA1 16p13.3 hemoglobin, alpha 1 HBQ1 16p13.3 hemoglobin, theta 1 LUC7L 16p13.3 LUC7-like (S. cerevisiae) DKFZP761D0211 16p13.3 hypothetical protein DKFZp761D0211 PDIP 16p13.3 protein disulfide isomerase, pancreatic RGS11 16p13.3 regulator of G-protein signalling 11 ARHGDIG 16p13.3 Rho GDP dissociation inhibitor (GDI) gamma AXIN1 16p13.3 axin 1 MRPL28 16p13.3 mitochondrial ribosomal protein L28 TMEM8 16p13.3 transmembrane protein 8 (five membrane-spanning domains) LOC388197 16 hypothetical gene supported by BC028568 NME4 16p13 non-metastatic cells 4, protein expressed in DECR2 16p13.3 2,4-dienoyl CoA reductase 2, peroxisomal
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 2422 52.8 467 - 2009 19497306
17 - 2433 50.6 446 - 2009 19497306
16 - 2389 - 456 - 2009 19497306
15 - 2257 - 283 - 2009 19497306
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Visualbipolar cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GGL (G protein gamma subunit-like)domain, that recruits G beta(5)
  • a DEP/DHEX domain that mediates interactions with the membrane anchor proteins R7BP and R9AP
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans c16c2.2
    Homologene
    FAMILY
  • R7 RGS family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • negative regulator of G protein signaling 11, functioning as GTPase-activating protein for G protein alpha subunits, G alpha i, G alpha o
  • RGS7, RGS11, and their binding partner GNB5 are localized to the dendritic tips of retinal ON bipolar cells (ON-BPC), and act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways
  • RGS7 and RGS11 act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways
  • RGS7 and RGS11 are the key GTPase accelerating proteins (GAPs) in the GRM6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses
  • action of RGS7 and RGS11 is required for the generation of rod ON-BC light responses with high sensitivity and speed
  • GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with GNB5
  • GTPase-accelerating protein specifically expressed in retinal ON-bipolar cells where it forms complexes with the atypical G protein beta subunit, GNB5, and transmembrane protein RGS9BP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS9BP is required for stable expression of RGS11-GNB5 in ON-bipolar cell dendrites
  • GPR179, is required for DBC function and recruits the regulators of G-protein signaling (RGS) proteins, RGS7 and RGS11, to the dendritic tips of the depolarizing bipolar cells (DBCs)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS