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FLASH GENE
Symbol RGS10 contributors: mct - updated : 30-05-2015
HGNC name regulator of G-protein signaling 10
HGNC id 9992
Location 10q26.11      Physical location : 121.259.339 - 121.302.222
Synonym symbol(s) RGSA
DNA
TYPE functioning gene
STRUCTURE 42.88 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 910 21.1 181 - 2007 17881498
RGS10A
5 - 859 19.5 167 - 2007 17881498
RGS10B
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunethymus     Homo sapiens
Nervousbrainmidbrain    Homo sapiens
 brainbasal nucleistriatum   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousdopaminergic neuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RGS domain
    • HOMOLOGY
    interspecies homolog to murine Rgs10
    Homologene
    FAMILY
  • regulator of G protein family
  • subfamily R12
    • CATEGORY regulatory , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • inhibiting signal transduction by increasing the GTPase activity of Gprotein alpha subunits thereby driving them into their inactive GDP-bound form
  • limits microglial-derived TNF secretion and regulates the functional outcome of inflammatory stimuli in the ventral midbrain
  • regulates ovarian cancer cell growth and survival
  • is a negative regulator of NFKB1 in microglia
  • plays likely an important role in determining macrophage activation responses
  • is an important regulator of cell survival and chemoresistance in ovarian cancer
  • plays an important function in osteoclast differentiation
  • may regulate dendritic cell proliferation and maturation, as well as the subsequent stimulation of T-cell proliferation and maturation, and osteoclast differentiation and activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text promoting chondrocyte differentiation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specificity of RGS10A as a key component in the TNFSF11-evoked signaling pathway for osteoclast differentiation, which may present a promising target for therapeutic intervention
    • cell & other
    REGULATION
    inhibited by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    RGS10 expression is suppressed in ovarian cancer chemoresistance
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    modulation of RGS10 activity in microglia may afford therapeutic benefit in the treatment of chronic neuroinflammatory conditions as well as neuroprotection against inflammation-related degeneration in Parkinson's disease (PD)
    cancerreproductiveovary
    HDAC1 and DNMT1 contribute to the suppression of RGS10 during acquired chemoresistance and support inhibition of HDAC1 and DNMT1 as an adjuvant therapeutic approach to overcome ovarian cancer chemoresistance
    ANIMAL & CELL MODELS
  • Rgs10-null mice display increased vulnerability to chronic systemic inflammation-induced degeneration of nigral dopaminergic (DA) neurons