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FLASH GENE
Symbol RGS1 contributors: mct - updated : 08-09-2017
HGNC name regulator of G-protein signaling 1
HGNC id 9991
Location 1q31.2      Physical location : 192.544.856 - 192.549.159
Synonym name
  • early response protein 1R20
  • B-cell activation protein BL34
  • immediate-early response 1, B-cell specific
  • Synonym symbol(s) IR20, BL34, IER1, 1R20
    DNA
    TYPE functioning gene
    STRUCTURE 4.30 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1403 23.73 209 - 2017 27445341
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alpha helical basic phosphoprotein
  • with eight consensus phosphorylation sites
  • a C terminal RGS domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to C.elegans EGL-10
    homolog to yeast SST2
    Homologene
    FAMILY
  • regulator of G-protein signaling family
  • CATEGORY regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • negative regulator of G-protein signaling 1, functioning as GTPase-activating protein for G protein alpha subunits, G alpha I and G alpha o
  • variations in GNAI2 and RGS1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to IgA nephropathy (IgAN)
    Variant & Polymorphism other
  • rs12022418 in RGS1 showed novel associations in IgA nephropathy (IgAN)
  • Candidate gene
    Marker
  • expression of RGS1, TAGAP, TNFSF14, and SH2B3 in peripheral blood mononuclear cells can predict Crohn Disease at least 9 months before the appearance of any clinical and serological signs of the disease
  • RGS1 expression may be a prognostic marker for risk stratification in multiple myeloma
  • role of RGS1 as a novel prognostic marker for melanoma given its impact on the survival associated with melanoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    promising target for the development of a new multiple myeloma therapy
    ANIMAL & CELL MODELS