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FLASH GENE
Symbol RGPD8 contributors: mct/npt - updated : 24/10/2008
HGNC name RANBP2-like and GRIP domain containing 8
HGNC id 9849
Location 2q12.3-q13      Physical location : 113.125.946 - 113.191.222
Synonym name
  • sperm membrane protein BS.63
  • RAN binding protein 2-like 1
  • Ran-binding protein 2-like 3
  • Synonym symbol(s) BS 63, RanBP2 alpha, RANBP2L1, RANBP2L3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text RanBP2 gene cluster
    STRUCTURE 65.78 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D2S340 - RANBP2 - D2S1735 - D2S2087 - D2S2087 - D2S1735 - RGPD8 - D2S1888 - qter
    Authors Nothwang (98)
    regionally located located in a duplication of the 5'end sequence of RANBP2 within 3Mb distal to RANBP2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 7164 205.1 1765 - Wang,Northwang
    - - 3325 205 904 - Wang,Northwang
    alternative 3' exon truncated
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    cell lineage germ cells at all stages of spermatogenesis
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the pentapeptide motif characteristic of nucleopore complex proteins
  • two RAN binding sites but lacking the cyclophilin A homologous domain of RANBP2
  • XFXFG or GLFG repetitive sequence motifs
  • HOMOLOGY
    intraspecies homolog to RAN binding protein 2 gene
    Homologene
    FAMILY
  • RANBP2 gene family/NPC family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nuclear envelope,pore
    text localized at the sites of nuclear pores in spermatids
    basic FUNCTION
  • testis-specific nucleoporin that possibly acts as a docking site and a cotransporter of Ran and transportin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAN binding
  • interacting with aF10 (complex performs the task of a carrier system in transporting aF10 into the nucleus of germ cells during spermiogenesis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS