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FLASH GENE
Symbol RGMA contributors: mct/ - updated : 07-06-2006
HGNC name RGM domain family, member A
HGNC id 30308
Location 15q26.1      Physical location : 93.586.636 - 93.632.443
Synonym name repulsive guidance molecule A
DNA
TYPE functioning gene
STRUCTURE 45.80 kb     4 Exon(s)    1 Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
Physical map
FURIN 15q26.1 furin (paired basic amino acid cleaving enzyme) FES 15q26.1 feline sarcoma oncogene MAN2A2 15q25 mannosidase, alpha, class 2A, member 2 MGC45386 15q26.1 Similar to RIKEN cDNA 1110033O09 gene LOC388176 15 LOC388176 SMAP-1 15q26.1 smooth muscle cell associated protein-1 MGC14386 15q26.1 similar to cyclin-E binding protein 1 (H. sapiens) PRC1 15q26.1 protein regulator of cytokinesis 1 VPS33B 15q26.1 vacuolar protein sorting 33B (yeast) LOC390638 15 similar to Golgi autoantigen, golgin subfamily a, 2; golgin-95; Golgi matrix protein GM130; SY11 protein SV2B 15q26.1 synaptic vesicle glycoprotein 2B SLCO3A1 15q26 solute carrier organic anion transporter family, member 3A1 NPM1P5 15q26.1 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 5 SIAT8B 15q26 sialyltransferase 8B (alpha-2, 8-sialyltransferase) FLJ32831 15q26.1 hypothetical protein FLJ32831 LOC388177 15 similar to histone H2A.F/Z variant isoform 2; purine-rich binding element protein B LOC390639 15 similar to Ferritin light chain (Ferritin L subunit) LOC390640 15 similar to Ankyrin repeat and SOCS box containing protein 9 (ASB-9) CHD2 15q26 chromodomain helicase DNA binding protein 2 RGMA 15q26.1 RGM domain family, member A LOC390641 15 similar to selenophosphate synthetase; selenium donor protein; selenide, water dikinase 1; selenophosphate synthase LOC388178 15 similar to Polyadenylate-binding protein 4 (Poly(A)-binding protein 4) (PABP 4) (Inducible poly(A)-binding protein) (iPABP) (Activated-platelet protein-1) (APP-1) FLJ11175 15q26.1-q26.2 hypothetical protein FLJ11175 LOC390642 15 similar to Glioma tumor suppressor candidate region gene 2 protein (p60)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3200 50 458 - -
variant 1/isoform 1
- - 3060 47.4 434 - -
variant 2/isoform 2
- - 3174 47.4 434 - -
variant 3/isoform 2
- - 3058 47.4 434 - -
variant 5/isoform 2
- - 3078 47.4 434 - -
variant 6/isoform 2
4 - 3227 49.2 450 - -
variant 4/isoform 3
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Nervousbrainmidbrain   
Reproductivefemale systemovary  highly
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text optic tectum of the midbrain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GPI anchored glycoprotein
  • a N terminal RGM domain
  • a C terminal RGM domain
  • HOMOLOGY
    Homologene
    FAMILY
  • repulsive guidance molecule (RGM) family
  • CATEGORY signaling , receptor nuclear
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • repulsive and specific guiding activity in the optic tectum
  • RGM/neogenin regulates cell fate by controlling the DAPK1 activity) (Fujita 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text development of nervous (visual) system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for neogenin (NEO1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS