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FLASH GENE
Symbol RGL4 contributors: npt - updated : 23-01-2006
HGNC name ral guanine nucleotide dissociation stimulator-like 4
HGNC id 31911
Location 22q11.23      Physical location : 24.033.047 - 24.041.358
Synonym name
  • Ral-GDS related protein Rgr
  • RalGDS related oncogene
  • Synonym symbol(s) Rgr, HRGR, RRGR, MGC119678, MGC119680
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text four alternatively spliced full-length transcripts (Leonardi)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2897 52.3 473 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Lymphoid/Immunespleen    
     thymus   highly
    Nervousbrain   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one Ras-GEF domain
  • HOMOLOGY
    interspecies ortholog to rabbit rgr
    homolog to chimpanzee LOC458697
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • acting as a guanyl-nucleotide exchange factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text small GTPase mediated signal transduction
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    or abnormally truncated transcript are involved in malignancies
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS