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FLASH GENE
Symbol RGL3 contributors: np/ - updated : 05-01-2006
HGNC name ral guanine nucleotide dissociation stimulator-like 3
HGNC id 30282
Location 19p13.2      Physical location : 11.504.731 - 11.530.018
Synonym name
  • Ral-GEF-like protein 3
  • RalGDS-like 3
  • RalGEF-like protein 3, mouse homolog
  • Synonym symbol(s) FLJ32585, FLJ00153, MGC126805, MGC138163, FLJ44275
    DNA
    TYPE functioning gene
    STRUCTURE 25.29 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2553 78 710 - -
    19 - 2571 - 716 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal homology with CDC25, RIT/RAS interaction domain
  • a Ras Binding Domain (RBD)
  • C terminal 99AA domain interacting in a GTP and effector loop-dependent manner with RIT and RAS
  • HOMOLOGY
    interspecies homolog to murine Ral-GEF-like protein 3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • exchange factor for Ral and downstream effector for both RIT and RAS (small GTPase)
  • with RALGDS and RGL2, can interact with activated Ras through their Ras Binding Domain (RBD), but may function as effectors for other Ras family members
  • crucial role in coupling activated Ras to activation of RAL, thus regulating several fundamental cell processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS