Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | RFX5 | contributors: mct/npt - updated : 12-03-2019 |
HGNC name | regulatory factor X, 5 (influences HLA class II expression) |
HGNC id | 9986 |
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Corresponding disease |
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Location | 1q21.3 Physical location : 151.313.115 - 151.319.769 | ||
Synonym name | regulatory factor X, 5 |
DNA |
TYPE | functioning gene |
STRUCTURE | 6.65 kb 11 Exon(s) |
Genomic sequence alignment details |
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10 Kb 5' upstream gene genomic sequence study |
regulatory sequence | HSs hypertensive site |
motif |
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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text | variants 1 and 2 encode the same protein |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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HOMOLOGY |
interspecies | homolog to murine Rfx5 |
Homologene |
FAMILY |
CATEGORY | regulatory , transcription factor |
CELLULAR PROCESS | nucleotide, transcription |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
pathway RFX5/HDAC2 implicated in interferon-gamma-mediated repression |
INTERACTION |
DNA | binding to the MHC promoter box X |
RNA |
small molecule |
cell & other |
REGULATION |
Other | DNA binding of RFX5 is inhibited by domains flanking its DNA binding domain, and both RFXAP and RFXB are required to overcome the inhibition of both domains |
ASSOCIATED DISORDERS |
corresponding disease(s) | BLS2C |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |