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FLASH GENE
Symbol RFX4 contributors: mct/npt - updated : 21-05-2008
HGNC name regulatory factor X, 4 (influences HLA class II expression)
HGNC id 9985
Location 12q23.3      Physical location : 106.977.032 - 107.156.580
Synonym name
  • regulatory factor X4, isoform c
  • transcription factor NYD-sp10
  • testis development protein NYD-SP10
  • cDNA FLJ77554, highly similar to Homo sapiens regulatory factor X, 4
    • Synonym symbol(s) NYD-SP10
    DNA
    TYPE functioning gene
    STRUCTURE 179.55 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3366 - 641 in the testis Blackshear, Matsushita (2005)
    - - 2188 - 563 in the testis Blackshear, Matsushita (2005)
    - - 3623 - 735 brain-specific isoform Matsushita (2005)
  • may act upstream of critical signaling pathways in the process of brain development
  • interacts with GPS2 to modulate transactivation of genes involved in brain morphogenesis, including CX3CL1
    • - - 3955 - 735 only in normal brain tissues Matsushita (2005)
    - - 2548 - 390 expressed in gliomas Matsushita (2005)
    - - 2470 - 370 expressed in gliomas Matsushita (2005)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
     brainlimbic systemhippocampus  
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RFX-type-DNA-binding domain
  • a dimerization domain
    • HOMOLOGY
    Homologene
    FAMILY
  • RFX family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be a transcriptional repressor rather than a transcriptional activator
  • first member of RFX family without transcriptional activation capacity and may be functioning through selective interactions with other RFX members in transcriptional regulation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RFX2
  • RFX3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS