Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RFX2 contributors: npt/mct - updated : 20-09-2016
HGNC name regulatory factor X, 2 (influences HLA class II expression)
HGNC id 9983
Location 19p13.3      Physical location : 5.993.175 - 6.110.664
Synonym name
  • trans-acting regulatory factor 2
  • DNA binding protein RFX2
  • HLA class II regulatory factor RFX2
  • Synonym symbol(s) FLJ14226
    DNA
    TYPE functioning gene
    STRUCTURE 117.49 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D19S177 - FUT5 - RFX2 - MLLT1 - D19S350 - C3 - VAV1 - cen
    Authors Doyle (96)
    Physical map
    LOC388496 19 LOC388496 LOC148066 19p13.3 zinc and ring finger 4 PLAC2 19p13.3 placenta-specific 2 LOC148064 19p13.3 similar to small nuclear ribonucleoprotein E SAFB2 19p13.3 scaffold attachment factor B2 SAFB 19p13.3-p13.2 scaffold attachment factor B LOC125988 19p13.3 hypothetical gene LOC125988 SCDR10 19p13.3 short-chain dehydrogenase/reductase 10 RPL36 19p13.3-p13.2 ribosomal protein L36 PRSS15 19p13.2 protease, serine, 15 MGC39581 19p13.3 hypothetical protein MGC39581 MGC24975 19p13.3 hypothetical protein MGC24975 LOC56931 19p13.3 hypothetical protein from EUROIMAGE 1967720 FUT6 19p13.3 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) NRTN 19p13.3 neurturin FUT3 19p13.3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) FUT5 19p13.3 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) NDUFA11 19p13.3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa CAPS 19p13.3 calcyphosine RANBP3 19p13.3 RAN binding protein 3 RFX2 19p13.3 regulatory factor X, 2 (influences HLA class II expression) BGR 19p13.3 bubblegum related protein LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC 2.7.4.3), cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615 CRB3 19p13.3 crumbs homolog 3 (Drosophila) FLJ22757 TUBB5 19p13.3 tubulin, beta, 5 TNFSF9 19p13.3 tumor necrosis factor (ligand) superfamily, member 9 TNFSF7 19p13 tumor necrosis factor (ligand) superfamily, member 7 LOC390878 19 similar to 60S ribosomal protein L7
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4039 - 698 - Morotomi-Yano (2002)
    18 - 4114 - 723 - Morotomi-Yano (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a specific DNA-binding domain
  • a dimerization domain
  • HOMOLOGY
    Homologene
    FAMILY
  • RFX family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transactivating DNA binding regulator 2,involved in MHC class II expression
  • may be important repressors of collagen gene transcription through a RFX binding site spanning the transcription start site
  • potentially an important transcriptional regulator in pachytene spermatocytes (Horvath 2009)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the MHC promoter box X
    RNA
    small molecule
    protein
  • interacting with RFX1, and ALMS1 (activate ALMS1 transcription during serum starvation-induced growth arrest, most likely as part of the ciliogenic program) (Purvis 2010)
  • RFX2 is essential for expression of several ciliogenic genes, including TTC25, which we show here is required for ciliogenesis, HH signaling, and left-right patterning
  • binding to the testis-specific histone HIST1H1T promoter may be required for transcriptional activation in primary spermatocytes (VanWert 2008)
  • TP73 directly activates the key regulators FOXJ1, RFX2, RFX3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS