basic FUNCTION
| may play a pivotal role in the formation and/or maintenance of lipid rafts, therefore regulating BCR-mediated signaling |
|
modulates TCR signals and is necessary for the fine-tuning of T cell-mediated immune responses ( |
|
cooperates with the uptake receptor to mediate cell entry of the double-stranded RNA analog, poly(I:C), which is critical for activation of TLR3 |
|
major lipid raft protein expressed by B cells, playing a critical role in poly(I:C) cellular uptake in human myeloid dendritic cells and epithelial cells |
|
involved in the nucleocapture complex triggering poly(I:C)-mediated TLR3 activation, and appears to act downstream of immune receptors in a cell type-specific manner |