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FLASH GENE
Symbol RFPL3 contributors: mct - updated : 04-09-2008
HGNC name ret finger protein-like 3
HGNC id 9980
Location 22q12.2      Physical location : 32.750.871 - 32.757.147
Synonym symbol(s) RP1-149A16.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text RFPL1, 2, 3 clustered on chromosome 22
STRUCTURE 6.28 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
FLJ20464 22q12.3 hypothetical protein FLJ20464 DRG1 22q12.2 developmentally regulated GTP binding protein 1 EIF4ENIF1 22q11.2 eukaryotic translation initiation factor 4E nuclear import factor 1 KIAA0542 22q12.2 KIAA0542 gene product PISD 22q12.2 phosphatidylserine decarboxylase LOC388894 22 similar to Phosphatidylserine decarboxylase proenzyme MGC50372 22q12.3 hypothetical protein MGC50372 FLJ23059 22q12.3 hypothetical protein FLJ23059 KIAA0645 22q12.2-q12.3 hypothetical protein FLJ23059 HSN44A4A 22q12.1-q12.3 hypothetical protein HSN44A4A YWHAH 22q12.2 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide LOC391329 22 similar to ribosomal protein S17 SLC5A1 22q12.3 solute carrier family 5 (sodium/glucose cotransporter), member 1 ADTB1L1 22q12.3 adaptin, beta 1-like 1 ADTB1L2 22q12.3 adaptin, beta 1-like 2 LOC150297 22q12.3 hypothetical protein LOC150297 RFPL2 22q12.3 ret finger protein-like 2 SLC5A4 22q12.1-q12.3 solute carrier family 5 (low affinity glucose cotransporter), member 4 LOC391330 22 similar to immunoglobulin lambda light chain VLJ region RFPL3 22q12.2 ret finger protein-like 3 RFPL3S 22q12.3 ret finger protein-like 3 antisense HSPC117 22q12 hypothetical protein HSPC117 BPIL2 22q12.3 bactericidal/permeability-increasing protein-like 2 FBXO7 22q12-q13 F-box only protein 7 SYN3 22q12.3 synapsin III TIMP3 22q12.13 tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1488 - 317 - Bonnefont (2008)
3 - 1214 - 288 - Bonnefont (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain at the onset of neurogenesis in differentiating human embryonic stem cells and in the developing human neocortex
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RING zinc finger
  • B box domain, linked to a coiled-coil domain
  • a C terminal B30-2 domain, spry domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Btn1a1
    intraspecies homolog to RFPL2
    Homologene
    FAMILY B box family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION may contribute to changes in cortical organization leading to the acquisition of human-specific behavioral traits
    CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by transactivated by the corticogenic transcription factor PAX6
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS