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FLASH GENE
Symbol RFC5 contributors: mct - updated : 01-12-2010
HGNC name replication factor C (activator 1) 5, 36.5kDa
HGNC id 9973
Location 12q24.23      Physical location : 118.454.507 - 118.470.038
Synonym name
  • activator 1 36 kDa subunit
  • replication factor C 5
    • Synonym symbol(s) RFC36, MGC1155
    DNA
    TYPE functioning gene
    STRUCTURE 25.02 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1025 LOC387888 12 LOC387888 FLJ21415 12q24.22 hypothetical protein FLJ21415 FLJ14627 12q24.22-q24.23 hypothetical protein FLJ14627 HRK 12q24.23 harakiri, BCL2 interacting protein (contains only BH3 domain) FBXW8 12q24.21 F-box and WD-40 domain protein 8 TSC 12q24.23 hypothetical protein FLJ20607 FBXO21 12q24.21 F-box only protein 21 NOS1 12q24.2-q24.31 nitric oxide synthase 1 (neuronal) KSR2 12q24.23 kinase suppressor of Ras-2 RFC5 12q24.2-q24.3 replication factor C (activator 1) 5, 36.5kDa WSB2 12q24.23 WD repeat and SOCS box containing protein 2 FLJ20674 12q24.23 hypothetical protein FLJ20674 PBP 12q24.23 prostatic binding protein JIK 12q24.2 prostatic binding protein SDS3 12q24.23 likely ortholog of mouse Sds3 LOC144747 12q24.23 hypothetical protein LOC144747 H11 LOC387889 12 hypothetical gene supported by U41745; NM_014891 MGC39827 12q24.23 hypothetical protein MGC39827 LOC387890 12 similar to hypothetical protein C130069F04 PRKAB1 12q24.1-q24.3 protein kinase, AMP-activated, beta 1 non-catalytic subunit CIT 12q24.2 citron (rho-interacting, serine/threonine kinase 21) LOC92558 12q24.31 hypothetical protein LOC92558 RAB35 12q24.31 RAB35, member RAS oncogene family GCN1L1 12q24.3 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) RPLP0 12q24.2 ribosomal protein, large, P0 PXN 12q24 paxillin FLJ23042 12q24.31 hypothetical protein FLJ23042 LOC283458 12q24.31 nucleoside diphosphate kinase B-like pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2485 36.1 319 - 1995 7774928
    11 - 2121 38.5 340 - 1995 7774928
    12 - 2180 36.1 319 - 1995 7774928
    12 - 2247 - 255 - 1995 7774928
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PCNA binding region,
  • an ATP binding domain
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
    • mono polymer heteromer , pentamer
    HOMOLOGY
    interspecies homolog to murine Rfc5
    homolog to Drosophila rfc3
    homolog to C.elegans pqn-38
    Homologene
    FAMILY
  • activator 1 small subunits family
    • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • component of complex A-1, DNA polymerase accessory protein "clamp loader", ATP dependent,required to assemble PCNA and polymerase delta on the DNA template
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa
  • complex ATAD5-RFC2-RFC5 functions in a fundamental DNA metabolism to suppress genomic instability
    • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • binding to PCNA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS